Document Detail

Serotonergic interhemispheric asymmetry: neurochemical and pharmaco-EEG evidence.
MedLine Citation:
PMID:  1722341     Owner:  NLM     Status:  MEDLINE    
1. Postmortem neurochemical investigations revealed interhemispheric asymmetry in the mediofrontal region of human brain. Significantly higher right hemisphere serotonin metabolite (5HIAA) content as well as increased maximal imipramine binding (IB) were found in the right hemisphere than in the left side. 2. IB did not show a gender difference in the mediofrontal area. However, women had higher IB in the right orbital frontal cortex than did men. 3. In vivo pharmaco-EEG results tend to support the postmortem neurochemical data. Intravenous chlorimipramine resulted in an asymmetric topographic distribution of the P300 auditory evoked potential, peak amplitudes were shifted to the right hemisphere.
M Arato; E Frecska; D J Maccrimmon; R Guscott; B Saxena; K Tekes; L Tothfalusi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-13     Completed Date:  1992-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  759-64     Citation Subset:  IM    
Hamilton Psychiatric Hospital, Ontario, Canada.
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MeSH Terms
Brain / anatomy & histology*,  physiology
Brain Chemistry / physiology*
Brain Mapping
Clomipramine / pharmacology
Electroencephalography / drug effects*
Evoked Potentials, Auditory / physiology
Hydroxyindoleacetic Acid / metabolism
Serotonin / physiology*
Reg. No./Substance:
303-49-1/Clomipramine; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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