Document Detail


Serotonergic hypotensive mechanism in rats: involvement of bulbospinal fibres.
MedLine Citation:
PMID:  3457905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study concerns the involvement of descending bulbospinal serotonergic pathways in blood pressure regulation in both normotensive and neurogenically hypertensive rats. We found that direct stimulation of serotonergic receptors of the spinal cord induced a depressor response which was prevented by prior catecholaminergic denervation in anaesthetized normotensive rats. Twenty-four hours after neurogenic hypertension, depletion of the serotonergic system provoked a further increase in blood pressure in conscious rats. We suggest that stimulation of pre-synaptic serotonergic receptors localized on spinal catecholaminergic neurons decreases blood pressure. This hypotensive mechanism could be activated after baroreflex deafferentation to prevent a further increase in blood pressure.
Authors:
A J Ramirez; S S Giarcovich; M A Enero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  4     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-06     Completed Date:  1986-06-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S47-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Female
Hypertension / drug therapy
Rats
Rats, Inbred Strains
Receptors, Serotonin / physiology*
Serotonin / physiology*,  therapeutic use
Spinal Cord / physiology*
Chemical
Reg. No./Substance:
0/Receptors, Serotonin; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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