| Serotonergic effects of smoking are independent from the human serotonin transporter gene promoter polymorphism: evidence from auditory cortical stimulus processing. | |
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MedLine Citation:
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PMID: 16025417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cigarette smoking has been associated with mood enhancing properties and modulating effects on serotonin activity. The loudness dependence (LD) of the auditory-evoked N1/P2-component has been related to serotonergic neurotransmission, i. e. the allelic variants in the promoter of the 5-hydroxytryptamine-transporter (5-HTT) gene (SCL6A4). Moreover, smoking behavior has been associated to the 5-HTT-genotype. It was hypothesized that cigarette smoking modulates the LD and this effect was expected to interact with the 5-HTT-genotype. METHODS: 5-HTT-genotype and LD were determined in 63 healthy smokers and 114 nonsmokers. RESULTS: LD was significantly affected by smoking status (p = 0.008) and 5-HTT-genotype (p = 0.045) but not by smoking*genotype-interaction or daily cigarette consumption. Current smokers exhibited a significantly weaker LD compared to nonsmokers. 5-HTT-genotype showed no significant effect on smoking behavior. DISCUSSION: The results indicate a higher serotonergic activity in smokers as compared to nonsmokers independent of 5-HTT-genotype. Since former smokers and never smokers showed similar LDs, the serotonin enhancing effect of smoking seems to be a characteristic state, which may contribute to the maintenance of smoking behavior. |
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Authors:
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J Gallinat; D Kunz; U E Lang; P Kalus; G Juckel; J Eggers; R Mahlberg; M Staedtgen; C Wernicke; H Rommelspacher; M N Smolka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacopsychiatry Volume: 38 ISSN: 0176-3679 ISO Abbreviation: Pharmacopsychiatry Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-18 Completed Date: 2005-08-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8402938 Medline TA: Pharmacopsychiatry Country: Germany |
Other Details:
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Languages: eng Pagination: 158-60 Citation Subset: IM |
Affiliation:
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Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Campus Mitte, Berlin, Germany. juergen.gallinat@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adult Auditory Cortex / physiology* Auditory Perception / physiology* DNA / genetics Evoked Potentials, Auditory / physiology Female Genotype Humans Loudness Perception / physiology Male Membrane Glycoproteins / genetics*, metabolism* Membrane Transport Proteins / genetics*, metabolism* Middle Aged Nerve Tissue Proteins / genetics*, metabolism* Polymorphism, Genetic / genetics Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction Serotonin / physiology* Serotonin Plasma Membrane Transport Proteins Smoking / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 50-67-9/Serotonin; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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