Document Detail


Serotonergic and dopaminergic influence of the duration of embryogenesis and intracapsular locomotion of Lymnaea stagnalis L.
MedLine Citation:
PMID:  15270248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of the dopaminergic and serotonergic system was studied during the embryonic development of the pond snail Lymnaea stagnalis, with special attention to the effect of dopamine and serotonin as well as their agonists and antagonists on the rotation of the veliger larvae, and to the effect of precursors and inhibitors of the synthetizing enzymes on the duration of the embryonic life. Serotonin, D-lysergic acid diethylamide and N,N-dimethyltryptamine increased at a concentration of 1 microM the rotation by 50%, 90% and 87% respectively, and among them D-Lysergic acid diethylamide was found to be the most potent agonist. Other serotonergic agonists and antagonists enhanced the frequency of the rotation (from 165% to 355%) at higher threshold concentrations in the following rank order: methysergid > tryptamine > 2,5-dimethoxy-4-iodoamphetamine > 5-carboxyamidotryptamine > bromo-lysergic acid diethylamide > 7-methyltryptamine. Application of 1-(2-methoxyphenyl) piperazine decreased the rotation by 76%. The reuptake inhibitor desipramine completely blocked the rotation and killed the embryos. Dopaminergic agonists accelerated the rotation by 62% to 233%, and their effect was ranged as follows: dopamine > apomorphine > m-tyramine approximately equal to p-tyramine. Chlorpromazine at 100 microM concentration killed the embryos. At a concentration of 100 microg/ml, tyrosine, the precursor of DA, slowed down the embryonic development by increasing the duration of the embryonic life from 8 to 10 days. Decarboxylase inhibitors, alpha-methyl-3,4-dihydroxyphenyl-alanine (25 microg/ml) and m-hydroxybenzylhydrazin (5 microg/ml), killed 50% of the embryos, meanwhile the rest hatched ten days later, compared to the control animals. The development was partially blocked by the serotonin precusor L-tryptophane (50 microg/ml). Trytophan hydroxylase blocker, p-chlorphenylalanine (50 microg/ml) resulted in a distortion of the body pattern of the embryos, and prevented the hatching of most (95%) of the animals.
Authors:
Adrienn Filla; L Hiripi; K Elekes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biologica Hungarica     Volume:  55     ISSN:  0236-5383     ISO Abbreviation:  Acta. Biol. Hung.     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-23     Completed Date:  2005-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8404358     Medline TA:  Acta Biol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  315-21     Citation Subset:  IM    
Affiliation:
Department of Experimental Zoology, Balaton Limnological Research Institute, Hungarian Academy of Sciences, PO Box 35, H-8237 Tihany, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Amphetamines / pharmacology
Animals
Apomorphine / pharmacology
Chlorpromazine / pharmacology
Dihydroxyphenylalanine / pharmacology
Dopamine / metabolism*,  pharmacology
Dopamine Agonists / pharmacology
Embryo, Nonmammalian / drug effects*
Embryonic Development / drug effects*
Fenclonine / pharmacology
Hydrazines / pharmacology
Locomotion
Lymnaea / embryology*
Lysergic Acid Diethylamide / analogs & derivatives*,  pharmacology
Methysergide / pharmacology
N,N-Dimethyltryptamine / pharmacology
Serotonin / analogs & derivatives*,  metabolism*,  pharmacology
Serotonin Agonists / pharmacology
Tryptamines / pharmacology
Tryptophan / pharmacology
Tyramine / pharmacology
Tyrosine / pharmacology
Chemical
Reg. No./Substance:
0/Amphetamines; 0/Dopamine Agonists; 0/Hydrazines; 0/Serotonin Agonists; 0/Tryptamines; 141817-19-8/1-(2,5-dimethyl-4-iodophenyl)-2-aminopropane; 14490-05-2/7-methyltryptamine; 361-37-5/Methysergide; 478-84-2/2-bromolysergic acid diethylamide; 50-37-3/Lysergic Acid Diethylamide; 50-53-3/Chlorpromazine; 50-67-9/Serotonin; 51-67-2/Tyramine; 55520-40-6/Tyrosine; 58-00-4/Apomorphine; 588-05-6/3-tyramine; 61-50-7/N,N-Dimethyltryptamine; 61-54-1/tryptamine; 63-84-3/Dihydroxyphenylalanine; 637-33-2/3-hydroxybenzylhydrazine; 73-22-3/Tryptophan; 7424-00-2/Fenclonine; 74885-09-9/5-carboxamidotryptamine

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