| Serotonergic descending inhibition in chronic pain: design, preliminary results and early cessation of a randomized controlled trial. | |
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MedLine Citation:
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PMID: 22021700 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PATIENTS AND METHODS: Three female CFS/FM patients, one female RA patient and two healthy women were randomly allocated to the experimental group (2 ml of citalopram intravenously) or the placebo group (2 ml of 0.9% NaCl intravenously). Participants performed a submaximal exercise protocol, preceded and followed by an assessment of endogenous pain inhibition. Seven days later, groups were crossed over. RESULTS: Significant side-effects were observed in all, but one participant immediately after intravenous administration of citalopram. One CFS/FM patient withdrew because of severe post-exertional malaise. CONCLUSION: It was decided that proceeding with the study would be unethical. No conclusion could be made regarding pain inhibition during exercise in CFS/FM compared to RA and controls. |
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Authors:
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Mira Meeus; Kelly Ickmans; Luc S DE Clerck; Greta Moorkens; Guy Hans; Sofie Grosemans; Jo Nijs |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 25 ISSN: 1791-7549 ISO Abbreviation: In Vivo Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 1019-25 Citation Subset: IM |
Affiliation:
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Department of Human Physiology, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Building L-Mfys, Pleinlaan 2, 1050 Brussels, Belgium. Mira.Meeus@vub.ac.be. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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