Document Detail


Serotonergic antidepressants and linezolid: a retrospective chart review and presentation of cases.
MedLine Citation:
PMID:  18624020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To report the results from a retrospective chart review looking at the combination of linezolid and serotonergic antidepressants and to report two cases of serotonin syndrome which were identified at our hospital.
CASE SUMMARY: During the retrospective chart review one case of serotonin syndrome was identified. A 65-year-old female was receiving escitalopram for the treatment of depression prior to admission. Linezolid therapy was initiated on admission and two days later the patient had a tonic-clonic seizure. Escitalopram was discontinued and the patient did not have any further seizure activity. In a second case, a 37-year-old male was receiving citalopram during hospitalization and was started on concomitant linezolid. The patient had myoclonus and was observed to be tremulous throughout therapy with linezolid. Ten days after discontinuation of linezolid the patient continued to have symptoms until the withdrawal of citalopram. The Naranjo probability scale scores the first case as possibly related and the second case as probably related to the combination.
DISCUSSION: It has been well documented in the literature that the combination of linezolid and serotonergic antidepressants may cause serotonin syndrome. In this retrospective chart review only one patient of 53 (1.8%) had symptoms highly suggestive of serotonin syndrome. A second patient continued to have symptoms of serotonin syndrome even after withdrawal of linezolid.
CONCLUSIONS: This retrospective review and subsequent case reports confirm the rare, but serious, potential of serotonin syndrome associated with the combination of linezolid and serotonergic antidepressants.
Authors:
Raymond A Lorenz; Amy M Vandenberg; Elizabeth A Canepa
Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of psychiatry in medicine     Volume:  38     ISSN:  0091-2174     ISO Abbreviation:  Int J Psychiatry Med     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-09-03     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0365646     Medline TA:  Int J Psychiatry Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / adverse effects*,  therapeutic use
Child, Preschool
Citalopram / adverse effects,  therapeutic use
Depressive Disorder / drug therapy*,  epidemiology
Drug Interactions
Epilepsy, Tonic-Clonic / chemically induced
Female
Humans
Male
Medical Records
Middle Aged
Myoclonus / chemically induced
Retrospective Studies
Serotonin Agents / adverse effects*,  therapeutic use
Serotonin Syndrome / chemically induced*,  diagnosis,  epidemiology
Serotonin Uptake Inhibitors / adverse effects,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Serotonin Agents; 0/Serotonin Uptake Inhibitors; 0DHU5B8D6V/Citalopram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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