Document Detail

Serotonergic agents in the treatment of fibromyalgia syndrome.
MedLine Citation:
PMID:  11918524     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate literature that discusses the treatment of fibromyalgia syndrome (FMS) with agents that involve the neurotransmitter serotonin. DATA SOURCES: Biomedical literature accessed through MEDLINE (1966-August 2001) and International Pharmaceutical Abstracts. DATA SYNTHESIS: The cause and pathophysiology of FMS remain elusive, although abnormalities in the serotonin pathway have been implicated. Several serotonergic agents have been studied for use in FMS. Trials and case reports focusing on the use of newer agents: the selective serotonin reuptake inhibitors, venlafaxine and tramadol, were reviewed. CONCLUSIONS: Current research suggests that the serotonergic agents may reduce at least some of the symptoms of FMS. However, medications that act on multiple neurotransmitters may prove to be more effective in symptom management. Additional long-term studies are required in order to validate these results.
Lisa J Miller; Kristy L Kubes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  36     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-28     Completed Date:  2002-07-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  707-12     Citation Subset:  IM    
Pharmacy Department, Memorial Hermann Southwest Hospital, Houston, TX 77074, USA.
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MeSH Terms
Clinical Trials as Topic
Fibromyalgia / drug therapy*,  metabolism
Serotonin / metabolism
Serotonin Uptake Inhibitors / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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