Document Detail

Serotonergic effects on feeding, but not hypothalamus-pituitary-adrenal secretion, are altered in ovine pregnancy.
MedLine Citation:
PMID:  22374755     Owner:  NLM     Status:  MEDLINE    
In ovine pregnancy, as in human pregnancy, hypothalamus-pituitary-adrenal activity is chronically increased. These studies were designed to test the hypotheses that expression of serotonergic genes and responsiveness to serotonin are increased in pregnancy. We tested the stimulatory effect of an acute, intracerebroventricular injection of the serotonin reuptake inhibitor fluoxetine on plasma ACTH and cortisol in ewes during late pregnancy or postpartum. We also tested the effect of lower-dose, longer-term stimulation by intracerebroventricular infusion of fluoxetine in pregnant and nonpregnant ewes over 6 days. Overall, we found that the stimulatory effect of fluoxetine on ACTH and cortisol was not significantly different between late-gestation and nonpregnant ewes, although the effect of acute fluoxetine administration was inversely related to plasma progesterone concentrations. Also, there were no differences in hypothalamic expression of the glucocorticoid and mineralocorticoid receptors, corticotropin-releasing hormone, AVP, the serotonin reuptake transporter, or the serotonin [5-hydroxytryptamine (5-HT)] receptors 5-HT(1A) and 5-HT(2A) with pregnancy or fluoxetine treatment. However, chronic fluoxetine infusion reduced food intake in the nonpregnant, but not pregnant, ewes. Expression of proopiomelanocortin mRNA in the hypothalamus was reduced in pregnant compared with nonpregnant ewes. Our results indicate that pregnancy does not increase responsiveness of ACTH and cortisol to serotonergic stimulation but, rather, that progesterone reduces the ACTH response. In addition, we found a reduced ability of serotonin to inhibit feeding in the pregnant ewes, consistent with a reduction in anorexic mechanisms in the pregnant state.
Melissa Lingis; Elaine Richards; Dana Perrone; Maureen Keller-Wood
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-28
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  302     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-16     Completed Date:  2012-07-17     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1231-8     Citation Subset:  IM    
Box 100274, Dept. of Physiology and Functional Genomics, Univ. of Florida, Gainesville, FL 32610, USA.
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MeSH Terms
Adrenocorticotropic Hormone / blood,  secretion
Blood Pressure / drug effects,  physiology
Feeding Behavior / physiology*
Fluoxetine / pharmacology
Gene Expression / drug effects,  physiology
Hydrocortisone / blood,  secretion
Hypothalamo-Hypophyseal System / drug effects,  physiology*,  secretion
Injections, Intraventricular
Pituitary-Adrenal System / drug effects,  physiology*,  secretion
Postpartum Period / physiology
Pregnancy, Animal / physiology*
Pro-Opiomelanocortin / genetics
Serotonin / physiology*
Serotonin Uptake Inhibitors / pharmacology
Grant Support
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 50-23-7/Hydrocortisone; 50-67-9/Serotonin; 54910-89-3/Fluoxetine; 66796-54-1/Pro-Opiomelanocortin; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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