| Serospecific protection of mice against intranasal infection with Bordetella pertussis. | |
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MedLine Citation:
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PMID: 2573215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of purified serospecific agglutinogens from Bordetella pertussis to protect mice against intranasal infection has been examined. Immunization with agglutinogen 2 protected mice against infection with 1.2.0 or 1.2.3 serotypes of B. pertussis, whereas immunization with agglutinogen 3 protected mice against infection with all serotypes. More importantly immunization with serospecific agglutinogen resulted in immune selection so that organisms recovered following infection did not express the immunizing antigen. The results are consistent with the suggestions that protection of children with whole cell pertussis vaccine is to some extent serospecific and that agglutinogens should be considered as constituents of acellular pertussis vaccines. |
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Authors:
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A Robinson; A R Gorringe; S G Funnell; M Fernandez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vaccine Volume: 7 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-11-28 Completed Date: 1989-11-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 321-4 Citation Subset: IM |
Affiliation:
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Division of Biologics, PHLS Centre for Applied Microbiology and Research, Porton, Salisbury, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Animals Bordetella pertussis / classification, immunology*, isolation & purification Fimbriae, Bacterial / ultrastructure Lung / microbiology Male Mice Mice, Inbred Strains Pertussis Vaccine / administration & dosage Serotyping Virulence Factors, Bordetella / administration & dosage*, immunology, isolation & purification Whooping Cough / immunology*, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Pertussis Vaccine; 0/Virulence Factors, Bordetella |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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