| Seroprevalence and specificity of NMO-IgG (anti-aquaporin 4 antibodies) in patients with neuropsychiatric systemic lupus erythematosus. | |
| | |
MedLine Citation:
|
PMID: 22038193 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Neuropsychiatric manifestations are present in 30-40% of patients with systemic lupus erythematosus (SLE). Recently, antibodies to aquaporin-4 (termed AQP4-Ab, or NMO-IgG), a water channel protein, were reported to be present in a subset of patients with SLE and neurological involvement. To evaluate the syndrome specificity and prevalence of serum NMO-IgG/anti-AQP4 antibodies in patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Sera of 76 patients with SLE and neurological symptoms, 50 of whom met the ACR case definitions of NPSLE, were tested for AQP4-Ab in an indirect immunofluorescence assay employing HEK293 cells transfected with recombinant human AQP4. Only one of the examined sera was positive for NMO-IgG/AQP4-Ab. This patient suffered from TM, ranging over two vertebral segments on spinal MRI. None of the 75 NPSLE without TM was found to be seropositive for NMO-IgG/AQP4-Ab. NMO-IgG/AQP4-Ab in NPSLE were present only in a patient with TM and were not detectable in NPSLE patients with other neurological manifestations. Testing for NMO-IgG/AQP4-Ab positivity should be considered in patients presenting with SLE and TM. Non-longitudinally extensive lesions do no not exclude NMO-IgG/AQP4-Ab in patients presenting with SLE and TM. |
| | |
Authors:
|
Jakub Závada; P Nytrová; K P Wandinger; S Jarius; R Svobodová; C Probst; V Peterová; D Tegzová; K Pavelka; J Vencovský |
Related Documents
:
|
2123913 - Reversal of hepatorenal syndrome in four patients by peroral misoprostol (prostaglandin... 7871633 - An assessment of immunoreactive epidermal growth factor in urine of patients with urolo... 10846253 - Serum adenosine deaminase levels in patients with psoriasis: a prospective case-control... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-29 |
Journal Detail:
|
Title: Rheumatology international Volume: - ISSN: 1437-160X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Institute of Rheumatology and First Faculty of Medicine, Charles University in Prague, Na Slupi 4, 128 50, Praha 2, Czech Republic, zavada@revma.cz. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determining the effectiveness of various treatment modalities in carpal tunnel syndrome by ultrasono...
Next Document: Just add tetrazole: 5-(2-Pyrrolo)tetrazoles are simple, highly potent anion recognition elements.