Document Detail


Seroprevalence of hepatitis B and C in type 2 diabetic patients.
MedLine Citation:
PMID:  16689194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many reports in the literature suggest that chronic hepatitis C virus (HCV) infection is associated with diabetes, but the results are conflicting. The aim of our study was to investigate the seroprevalence of hepatitis B virus (HBV) and HCV infections in type 2 diabetes mellitus (DM) patients. METHODS: We collected 820 consecutive type 2 diabetic patients attending 2 of 5 outpatient endocrinology clinics in Far Eastern Memorial Hospital from March to July 2003. The control group consisted of 905 subjects who came for medical check-ups at the Family Medicine Department. We determined hepatitis B surface antigen (HBsAg) and anti-HCV in both groups, using third-generation microparticle enzyme immunoassay. RESULTS: No significant difference was found between type 2 DM patients and the control group for seropositivity of HBsAg (13.5% versus 12.4%; odds ratio [OR] = 1.09; 95% confidence interval [CI]: 0.77-1.55; p = 0.441), but anti-HCV seropositivity was detected in 6.8% of patients and 2.6% of the control subjects (OR = 2.87; 95% CI: 1.51-5.46; p < 0.001). In anti-HCV-positive DM patients, abnormal alanine aminotransferase was observed in 61.8%, compared with only 34.2% of anti-HCV-negative DM patients (p < 0.001). We did not observe any difference in risk factors for HCV infection between anti-HCV-positive and -negative DM patients. CONCLUSION: The rate of seropositive anti-HCV is 2.8 times higher in type 2 DM patients than non-diabetic control subjects.
Authors:
Hua-Fen Chen; Chung-Yi Li; Peter Chen; Ting-Ting See; Hsin-Yu Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Chinese Medical Association : JCMA     Volume:  69     ISSN:  1726-4901     ISO Abbreviation:  J Chin Med Assoc     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-12     Completed Date:  2006-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101174817     Medline TA:  J Chin Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  146-52     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Department of Internal Medicine, Far-Eastern Memorial Hospital, Panchiao, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alanine Transaminase / blood
Body Mass Index
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / virology*
Female
Hepatitis B Antibodies / blood*
Hepatitis B Surface Antigens / blood
Hepatitis C Antibodies / blood*
Humans
Male
Middle Aged
Seroepidemiologic Studies
Chemical
Reg. No./Substance:
0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens; 0/Hepatitis C Antibodies; EC 2.6.1.2/Alanine Transaminase

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