Document Detail

Seronegative Sjögren syndrome with asymptomatic autoimmune sclerosing pancreatitis.
MedLine Citation:
PMID:  16362447     Owner:  NLM     Status:  MEDLINE    
We report two elderly patients with seronegative Sjögren syndrome who showed benign swelling of the pancreas on computed tomography. Immunostaining of the biopsied lip tissue or serum examination confirmed an increase in production of IgG4, leading to a diagnosis of autoimmune sclerosing pancreatitis (ASP) as a cause of the asymptomatic swelling of the pancreas. Sicca symptoms and ASP spontaneously improved in one patient, and the other responded well to oral prednisolone. Seronegative Sjögren syndrome and ASP can concurrently occur as a clinical manifestation of the IgG4-related systemic disorder, particularly in elderly subjects, and, in such a case, corticosteroid may be a potent therapeutic option.
Masayuki Matsuda; Hideaki Hamano; Takuhiro Yoshida; Takahisa Gono; Takeshi Uehara; Shigeyuki Kawa; Shu-ichi Ikeda
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-12-15
Journal Detail:
Title:  Clinical rheumatology     Volume:  26     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  117-9     Citation Subset:  IM    
Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi, Matsumoto, Japan.
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MeSH Terms
Autoimmune Diseases / complications,  diagnosis*,  drug therapy
Immunoglobulin G / immunology*
Pancreatitis / complications,  diagnosis*,  drug therapy
Sclerosis / complications,  diagnosis*,  drug therapy
Sjogren's Syndrome / blood,  complications*,  immunology
Reg. No./Substance:
0/Immunoglobulin G

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