| Serology of Chlamydia trachomatis in infants. | |
| | |
MedLine Citation:
|
PMID: 6750008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sera from 502 infants with pneumonia were tested for antibodies to Chlamydia trachomatis by the microimmunofluorescence test; 175 (34.9%) were positive for IgM antibodies (titer, greater than or equal to 1:32). Chlamydiae were recovered from 42 (46.2%) of 91 IgM antibody-positive infants as compared with six (3.3%) of 181 IgM antibody-negative infants (P less than 0.0001). Two (4%) of 46 of the infants with inclusion conjunctivitis, but not pneumonia, had titers of IgM antibody of greater than or equal to 1:32; both shed the organism from the rectum. IgM antibody to C. trachomatis is not maternally transmitted to infants and was detected at a low rate (1.1%) in infants with nonpneumonic conditions. Diagnosis of pneumonia due to Chlamydia in infants by isolation of the agent is slow and unreliable. High levels of IgM antibody (greater than 1:32) appear to reflect a systemic chlamydial infection and offer the possibility of a same-day diagnosis. Thus, the detection of specific IgM antibodies to C. trachomatis may be the method of choice in diagnosing chlamydial pneumonia in infants. |
| | |
Authors:
|
J Schachter; M Grossman; P H Azimi |
Related Documents
:
|
169688 - Nosocomial and maternally acquired herpesvirus hominis infections. a report of four fat... 8452648 - In utero treatment of toxoplasmic fetopathy with the combination pyrimethamine-sulfadia... 2230178 - Infected cephalhaematoma and neonatal osteomyelitis. 7188718 - Congenital torulopsis glabrata infection in man. 21868028 - Deaths in preterm infants: changing pathology over 2 decades. 17273408 - A comparison of blood pressure in term, low birth-weight infants of smoking and nonsmok... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: 146 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1982 Oct |
Date Detail:
|
Created Date: 1982-12-03 Completed Date: 1982-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 530-5 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Viral
/
analysis* Chlamydia Infections / diagnosis*, immunology Chlamydia trachomatis / immunology*, isolation & purification Conjunctivitis, Inclusion / immunology Fluorescent Antibody Technique Humans Immunity, Maternally-Acquired Immunoglobulin G / analysis Immunoglobulin M / analysis* Infant Infant, Newborn Pneumonia / etiology*, immunology Prospective Studies |
| Grant Support | |
ID/Acronym/Agency:
|
EY-02216/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antibody to Ebola virus in guinea pigs: Tandala, Zaire.
Next Document: Subendothelial deposition of von Willebrand's factor requires the presence of endothelial cells.