Document Detail


Serology of Chlamydia trachomatis in infants.
MedLine Citation:
PMID:  6750008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sera from 502 infants with pneumonia were tested for antibodies to Chlamydia trachomatis by the microimmunofluorescence test; 175 (34.9%) were positive for IgM antibodies (titer, greater than or equal to 1:32). Chlamydiae were recovered from 42 (46.2%) of 91 IgM antibody-positive infants as compared with six (3.3%) of 181 IgM antibody-negative infants (P less than 0.0001). Two (4%) of 46 of the infants with inclusion conjunctivitis, but not pneumonia, had titers of IgM antibody of greater than or equal to 1:32; both shed the organism from the rectum. IgM antibody to C. trachomatis is not maternally transmitted to infants and was detected at a low rate (1.1%) in infants with nonpneumonic conditions. Diagnosis of pneumonia due to Chlamydia in infants by isolation of the agent is slow and unreliable. High levels of IgM antibody (greater than 1:32) appear to reflect a systemic chlamydial infection and offer the possibility of a same-day diagnosis. Thus, the detection of specific IgM antibodies to C. trachomatis may be the method of choice in diagnosing chlamydial pneumonia in infants.
Authors:
J Schachter; M Grossman; P H Azimi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  146     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  530-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / analysis*
Chlamydia Infections / diagnosis*,  immunology
Chlamydia trachomatis / immunology*,  isolation & purification
Conjunctivitis, Inclusion / immunology
Fluorescent Antibody Technique
Humans
Immunity, Maternally-Acquired
Immunoglobulin G / analysis
Immunoglobulin M / analysis*
Infant
Infant, Newborn
Pneumonia / etiology*,  immunology
Prospective Studies
Grant Support
ID/Acronym/Agency:
EY-02216/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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