| Serological, virological and histopathological study of an outbreak of sleeping disease in farmed rainbow trout Oncorhynchus mykiss. | |
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MedLine Citation:
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PMID: 17465304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective longitudinal survey for sleeping disease (SD) was carried out over a 20 wk period on a caged freshwater population of farmed rainbow trout Oncorhynchus mkyiss. Pancreas, heart and red and white skeletal muscle were examined histologically and the presence and severity of lesions recorded. Sera were tested for viraemia with Salmonid Alphavirus (SAV) and for virus neutralizing (VN) antibodies. Viraemia was detected for 4 wk, beginning at Week 6 and with a peak prevalence of 57.9% at Week 7. Clinical signs and mortalities appeared at Week 8. Total mortality in the study cage from Week 6 onward was 6.3 %, but other cages at the site had mortality levels of up to 47.2%. VN antibodies were first detected at Week 9, with seroprevalence increasing to 80% by the end of the study (Week 20). Geometric mean antibody titres peaked at 1/89.4 at Week 17. Histological lesions were first detected at Week 7 (pancreas only), before increasing in prevalence and severity to peak at Weeks 9 and 10. The majority of lesions were resolved by Week 15. |
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Authors:
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D A Graham; H L Jewhurst; M F McLoughlin; E J Branson; K McKenzie; H M Rowley; D Todd |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diseases of aquatic organisms Volume: 74 ISSN: 0177-5103 ISO Abbreviation: Dis. Aquat. Org. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-04-30 Completed Date: 2007-09-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807037 Medline TA: Dis Aquat Organ Country: Germany |
Other Details:
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Languages: eng Pagination: 191-7 Citation Subset: IM |
Affiliation:
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Department of Agriculture and Rural Development, Veterinary Sciences Division, Stoney Road, Stormont, Belfast BT4 3SD, UK. david.graham@afbini.gov.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alphavirus
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immunology,
pathogenicity* Alphavirus Infections / epidemiology, immunology, pathology, veterinary* Animals Antibodies, Viral / blood Disease Outbreaks / veterinary Fish Diseases / epidemiology, pathology*, virology* Fisheries Longitudinal Studies Muscle, Skeletal / pathology Myocardium / pathology Oncorhynchus mykiss / virology* Pancreas / pathology Prospective Studies Seroepidemiologic Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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