Document Detail

Serological, virological and histopathological study of an outbreak of sleeping disease in farmed rainbow trout Oncorhynchus mykiss.
MedLine Citation:
PMID:  17465304     Owner:  NLM     Status:  MEDLINE    
A prospective longitudinal survey for sleeping disease (SD) was carried out over a 20 wk period on a caged freshwater population of farmed rainbow trout Oncorhynchus mkyiss. Pancreas, heart and red and white skeletal muscle were examined histologically and the presence and severity of lesions recorded. Sera were tested for viraemia with Salmonid Alphavirus (SAV) and for virus neutralizing (VN) antibodies. Viraemia was detected for 4 wk, beginning at Week 6 and with a peak prevalence of 57.9% at Week 7. Clinical signs and mortalities appeared at Week 8. Total mortality in the study cage from Week 6 onward was 6.3 %, but other cages at the site had mortality levels of up to 47.2%. VN antibodies were first detected at Week 9, with seroprevalence increasing to 80% by the end of the study (Week 20). Geometric mean antibody titres peaked at 1/89.4 at Week 17. Histological lesions were first detected at Week 7 (pancreas only), before increasing in prevalence and severity to peak at Weeks 9 and 10. The majority of lesions were resolved by Week 15.
D A Graham; H L Jewhurst; M F McLoughlin; E J Branson; K McKenzie; H M Rowley; D Todd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of aquatic organisms     Volume:  74     ISSN:  0177-5103     ISO Abbreviation:  Dis. Aquat. Org.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807037     Medline TA:  Dis Aquat Organ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
Department of Agriculture and Rural Development, Veterinary Sciences Division, Stoney Road, Stormont, Belfast BT4 3SD, UK.
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MeSH Terms
Alphavirus / immunology,  pathogenicity*
Alphavirus Infections / epidemiology,  immunology,  pathology,  veterinary*
Antibodies, Viral / blood
Disease Outbreaks / veterinary
Fish Diseases / epidemiology,  pathology*,  virology*
Longitudinal Studies
Muscle, Skeletal / pathology
Myocardium / pathology
Oncorhynchus mykiss / virology*
Pancreas / pathology
Prospective Studies
Seroepidemiologic Studies
Time Factors
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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