Document Detail


Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein.
MedLine Citation:
PMID:  9619577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical and histopathological correlations of immunoreactivity to Chlamydia trachomatis and to epitopes of the C. trachomatis 60 kDa heat shock protein (hsp60) among women with ectopic pregnancy were evaluated in a case-control study. Serological responses to 13 synthetic peptides corresponding to major epitopes of the chlamydial hsp60 were determined in 67 women treated for ectopic pregnancy and 45 women with uncomplicated pregnancy in utero. Plasma cell salpingitis was detected in 29 (43.3%) of the ectopic patients. Its presence correlated with antibodies to two hsp60 epitopes, encompassing amino acids 260-271 and 411-422 (P = 0.02). Antibodies to these two epitopes, along with five other epitopes, also correlated with peritubal adhesion formation in ectopic pregnant patients (P < 0.01). Antibodies to epitopes 260-271 and 188-199 also correlated with a history of pelvic inflammatory disease (PID; P = 0.05). Patients with ectopic pregnancy were also more likely than their intrauterine pregnant controls to have present anti-chlamydial immunoglobulin G (P < 0.005). Women positive for both C. trachomatis and hsp60 epitope antibodies had an increased prevalence over controls of salpingitis, pelvic adhesions or history of PID (P < 0.05). In contrast, patients who were positive for only C. trachomatis antibodies or only hsp60 epitope antibodies did not differ from antibody-negative patients in each of these categories.
Authors:
I Sziller; S S Witkin; M Ziegert; Z Csapó; A Ujházy; Z Papp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-08-06     Completed Date:  1998-08-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1088-93     Citation Subset:  IM    
Affiliation:
First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigen-Antibody Reactions*
Chaperonin 60 / immunology*
Chlamydia trachomatis / metabolism*
Epitopes / immunology*
Female
Humans
Pelvic Inflammatory Disease / immunology
Pelvis
Plasma Cells / pathology
Pregnancy
Pregnancy, Ectopic / immunology*
Reference Values
Salpingitis / immunology,  pathology
Tissue Adhesions / immunology,  pathology
Chemical
Reg. No./Substance:
0/Chaperonin 60; 0/Epitopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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