Document Detail


Serological matching for D locus antigens improves kidney allograft survival in rhesus monkeys.
MedLine Citation:
PMID:  151948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective study performed in unrelated, unimmunized rhesus monkeys revealed that serological matching for D-associated Ia1 antigens improves kidney allograft prognosis, provided that the recipients are nonreactive in mixed lymphocyte cultures (MLC) against their donors. MLC-negative host-donor combinations showed a more than 3-fold increase in the mean survival time as compared with MLC-positive combinations. Apparently, compatibility for the most important MLC-stimulating determinants is required for a significant improvement in graft survival. On the other hand, matching for A and B loci antigens did not play a decisive role. Since the relatively simple matching on the basis of identity for Ia1 (or DR) antigens yields a rather high proportion of MLC-nonreactive combinations, this method is likely to become an essential addition to the conventional matching procedures, also in clinical organ transplantation.
Authors:
A A van Es; H Balner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  26     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Graft Survival*
Haplorhini
Isoantigens*
Kidney Transplantation*
Lymphocyte Culture Test, Mixed
Macaca / immunology*
Macaca mulatta / immunology*
Male
Chemical
Reg. No./Substance:
0/Isoantigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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