Document Detail

Serological and immunohistochemical determination of von Willebrand factor antigen in serum and biopsy specimens from patients with arteritis temporalis and polymyalgia rheumatica.
MedLine Citation:
PMID:  2189625     Owner:  NLM     Status:  MEDLINE    
Von Willebrand factor antigen (vWF-Ag) levels in serum from patients with untreated polymyalgia rheumatica (PMR) and arteritis temporalis (AT) were measured using an ELISA technique. The level in patients with AT was significantly higher (median 229%, range 182-358%) than in patients with PMR (median 190%, range 131-390%) and in controls (median 179%, range 65-296%). Using an immunoperoxidase technique and biopsy specimens from 21 temporal arteries (7 patients with AT, 7 with PMR and 7 with other diseases), vWF-Ag was localized in the luminal endothelium in all cases. VWF-Ag was also present in many new vessels along the lamina elastica of the artery wall in all patients with AT, but not in patients with PMR. We relate the higher vWF-Ag level in these patients to an increased vWF-Ag production by endothelian cells in new, proliferating vessels in the artery wall.
A Olsson; P Elling; H Elling
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  8     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    1990 Jan-Feb
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  IM    
Department of Rheumatology, Viborg County Hospital, Denmark.
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MeSH Terms
Aged, 80 and over
Antigens / analysis*,  blood
Endothelium, Vascular / immunology
Enzyme-Linked Immunosorbent Assay
Giant Cell Arteritis / immunology*
Immunoenzyme Techniques
Middle Aged
Polymyalgia Rheumatica / immunology*
von Willebrand Factor / immunology*
Reg. No./Substance:
0/Antigens; 0/Von Willebrand antigen; 0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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