Document Detail

Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthma.
MedLine Citation:
PMID:  10706488     Owner:  NLM     Status:  MEDLINE    
There is evidence that infection with Chlamydia pneumoniae is associated with asthma of recent onset and that it can influence the severity of asthma. This has led to the suggestion that macrolide antibiotics may be useful in the treatment of asthma in subjects infected with C. pneumoniae. This study examined the association between immunoglobulin (Ig)G and IgA titres to C. pneumoniae and the severity of asthma. IgG and IgA antibodies to C. pneumoniae were measured in 619 subjects with asthma (18-60 yrs), using the microimmunofluoresence method. Subjects were asked about their use of asthma medicines, symptoms, previous hospitalization for asthma, smoking status and age of onset of asthma. In subjects with IgG titres of > or =1:64 and/or IgA titres > or =1:16 (n=212), spirometry was performed and peak expiratory flow rate (PEFR) and symptoms were recorded twice daily for 4 weeks on a diary card. The use of high dose inhaled steroids was associated with an increase of 74.1% in the titre of IgG antibodies (p=0.04) and an increase of 70.6% in the titre of IgA antibodies (p=0.0001) when compared with the use of low dose inhaled steroids. There was an inverse association between IgG antibodies and forced expiratory volume in one second (FEV1) as a percentage of predicted in those subjects with elevated IgG and/or IgA (p=0.04). In this group IgA antibodies were also associated with a higher daytime symptom score (p=0.04). Higher titres of antibodies to Chlamydia pneumoniae appears to be associated with markers of asthma severity. This raises the possibility that chronic infection with Chlamydia pneumoniae leads to an increase in the severity of asthma. Studies aimed at eradicating chronic infection with Chlamydia pneumoniae are necessary to determine whether or not this is the case.
P N Black; R Scicchitano; C R Jenkins; F Blasi; L Allegra; J Wlodarczyk; B C Cooper
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  15     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-28     Completed Date:  2000-03-28     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM    
Dept of Medicine, University of Auckland, New Zealand.
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MeSH Terms
Administration, Inhalation
Asthma / complications*,  microbiology
Beclomethasone / administration & dosage
Chlamydia Infections / complications*,  drug therapy,  immunology
Chlamydophila pneumoniae* / immunology
Double-Blind Method
Glucocorticoids / administration & dosage
Immunoglobulin A / immunology
Immunoglobulin G / immunology
Logistic Models
Severity of Illness Index
Reg. No./Substance:
0/Glucocorticoids; 0/Immunoglobulin A; 0/Immunoglobulin G; 4419-39-0/Beclomethasone

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