Document Detail


Serological and clinical features of patients with myasthenia gravis in north Indian population.
MedLine Citation:
PMID:  20199203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myasthenia gravis (MG) is a disorder of neuromuscular junction associated with presence of antibodies against nicotinic acetylcholine receptors (nAChRs). Here, we compared the clinical and serological profile of seropositive myasthenia gravis (SPMG) and seronegative myasthenia gravis (SNMG) patients. Anti-AChR antibody was measured using radio receptor immunoassay and correlated with clinical phenotype in 250 MG patients over 2004 and 2006. Out of 250 MG patients, 161 (64.4%) were males (male:female = 1.8:1). SNMG patients formed 40% (n = 101) of our MG patients which is much higher as compared to Caucasian and Oriental population (15%-20%). The median age of disease onset in SPMG was significantly higher than SNMG patients (43 years; range 8-74 vs. 35 years; range 4-72, p = .022). A bimodal peak of age of disease onset in both genders was observed (first peak in second-third decades and second one in fifth-sixth decades). Among the MG patients with late-onset of disease, male were significantly higher compared to Caucasian and Oriental MG population (p = .047). MG patients with thymoma were significantly older and consisted of higher percent of males. Bulbar symptoms and severe grade (IIB+ III+ IV) at disease onset were more frequent in SPMG than SNMG patients.
Authors:
Hamid Suhail; Vivekanandhan Subbiah; Sumit Singh; Madhuri Behari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Autoantibodies / blood
Diagnosis, Differential
Female
Humans
India / epidemiology
Male
Middle Aged
Myasthenia Gravis / classification,  epidemiology,  pathology*
Neurologic Examination
Receptors, Cholinergic / immunology
Sex Factors
Thymectomy
Thymus Gland / pathology,  radiography
Tomography, X-Ray Computed
Young Adult
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Receptors, Cholinergic

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