Document Detail

Serological assessment of rubella during pregnancy.
MedLine Citation:
PMID:  5448797     Owner:  NLM     Status:  MEDLINE    
In 45 patients with rubella-like illnesses during pregnancy serological tests showed that the clinical diagnosis had been accurate in only 20. Since only 16 of these patients had presented for laboratory investigations within a week of the onset of symptoms, the value of haemagglutination-inhibition tests was considerably reduced; the diagnosis in these cases was confirmed by complement-fixation and rubella-specific IgM tests.Of 172 patients exposed to a rubella-like illness, only 17 were seronegative; 105 sought advice within two weeks of exposure, and therefore the haemagglutination-inhibition antibody tests were useful in determining immunity. Since the clinical diagnosis of rubella was proved incorrect in a number of cases, these pregnancies were saved. Hence both doctors and patients should report both exposure to and rubella-like illnesses as early as possible, so that laboratory investigations may be carried out without delay.
J E Banatvala; J M Best; J Bertrand; N A Bowern; S M Hudson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  3     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1970 Aug 
Date Detail:
Created Date:  1970-09-28     Completed Date:  1970-09-28     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Therapeutic
Complement Fixation Tests
Fetus / microbiology
Hemagglutination Inhibition Tests
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Pregnancy Complications, Infectious / diagnosis*
Rubella / diagnosis*
Rubella virus / isolation & purification
Serologic Tests
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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