| Serological and Virological Analysis of Maternal and Fetal Blood Samples in Prenatal Human Parvovirus B19 Infection. | |
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MedLine Citation:
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PMID: 22275404 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. Intrauterine parvovirus B19 (B19V) infection can be asymptomatic or may cause severe fetal complications. Information on serological and virological findings of infection in the fetus is scarce.Methods. We determined B19V-DNA and anti-B19V antibodies in maternal and fetal blood samples obtained from 41 pregnancies that were complicated by prenatal B19V infection. Most fetuses presented with moderate to severe anemia or hydrops.Results. At the time of fetal blood sampling, all mothers were B19V-DNA positive and B19V-IgG positive. B19V-IgM was detected in 95% of maternal blood samples. B19V-DNA, B19V-IgM, and B19V-IgG were detected in 100%, 28%, and 24% of fetal blood samples, respectively. The probability of a positive B19V-IgG or B19V-IgM finding in fetal blood increased with gestational age. B19V-IgG levels in maternal blood did not correlate with the likelihood of a positive B19V-IgG test in the fetus. The presence of B19V-IgG in fetal blood was accompanied by lower B19V-DNA levels and less severe clinical findings.Conclusions. The lack of B19V-IgG in fetuses with B19V-derived anemia or hydrops is most likely due to a limited materno-fetal transfer of IgG and a poor fetal antibody response. Fetal B19V infection is poorly controlled in the absence of specific antibodies. |
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Authors:
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Johannes Weiffenbach; Rainer Bald; Karl-Philipp Gloning; Sabine Minderer; Barbara C Gärtner; Andrea Weidner; Monika Hanke; Martin Enders |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: - ISSN: 1537-6613 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory Prof. G. Enders and Partners and Institute of Virology, Infectious Diseases and Epidemiology, Stuttgart. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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