| Serological and virological analysis of maternal and fetal blood samples in prenatal human parvovirus b19 infection. | |
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MedLine Citation:
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PMID: 22275404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intrauterine parvovirus B19 (B19V) infection can be asymptomatic or may cause severe fetal complications. Information on serological and virological findings of infection in the fetus is scarce. METHODS: We determined B19V-DNA and anti-B19V antibodies in maternal and fetal blood samples obtained from 41 pregnancies that were complicated by prenatal B19V infection. Most fetuses presented with moderate to severe anemia or hydrops. RESULTS: At the time of fetal blood sampling, all mothers were B19V-DNA positive and B19V-IgG positive. B19V-IgM was detected in 95% of maternal blood samples. B19V-DNA, B19V-IgM, and B19V-IgG were detected in 100%, 28%, and 24% of fetal blood samples, respectively. The probability of a positive B19V-IgG or B19V-IgM finding in fetal blood increased with gestational age. B19V-IgG levels in maternal blood did not correlate with the likelihood of a positive B19V-IgG test in the fetus. The presence of B19V-IgG in fetal blood was accompanied by lower B19V-DNA levels and less severe clinical findings. CONCLUSIONS: The lack of B19V-IgG in fetuses with B19V-derived anemia or hydrops is most likely due to a limited materno-fetal transfer of IgG and a poor fetal antibody response. Fetal B19V infection is poorly controlled in the absence of specific antibodies. |
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Authors:
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Johannes Weiffenbach; Rainer Bald; Karl-Philipp Gloning; Sabine Minderer; Barbara C Gärtner; Andrea Weidner; Monika Hanke; Martin Enders |
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Publication Detail:
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Type: Journal Article Date: 2012-01-24 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 205 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-08 Completed Date: 2012-03-27 Revised Date: 2012-06-04 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 782-8 Citation Subset: AIM; IM |
Affiliation:
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Laboratory Prof. G. Enders and Partners and Institute of Virology, Infectious Diseases and Epidemiology, Stuttgart, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / etiology Antibodies, Viral / blood* DNA, Viral / blood* Erythema Infectiosum / immunology*, virology Female Fetal Blood / immunology*, virology Gestational Age Humans Hydrops Fetalis / etiology, ultrasonography Immunoglobulin G / blood Immunoglobulin M / blood Parvovirus B19, Human / immunology* Pregnancy Pregnancy Complications, Infectious / immunology*, virology Retrospective Studies Statistics, Nonparametric Ultrasonography, Prenatal Viral Load Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/DNA, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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