Document Detail

Serological and virological analysis of maternal and fetal blood samples in prenatal human parvovirus b19 infection.
MedLine Citation:
PMID:  22275404     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intrauterine parvovirus B19 (B19V) infection can be asymptomatic or may cause severe fetal complications. Information on serological and virological findings of infection in the fetus is scarce.
METHODS: We determined B19V-DNA and anti-B19V antibodies in maternal and fetal blood samples obtained from 41 pregnancies that were complicated by prenatal B19V infection. Most fetuses presented with moderate to severe anemia or hydrops.
RESULTS: At the time of fetal blood sampling, all mothers were B19V-DNA positive and B19V-IgG positive. B19V-IgM was detected in 95% of maternal blood samples. B19V-DNA, B19V-IgM, and B19V-IgG were detected in 100%, 28%, and 24% of fetal blood samples, respectively. The probability of a positive B19V-IgG or B19V-IgM finding in fetal blood increased with gestational age. B19V-IgG levels in maternal blood did not correlate with the likelihood of a positive B19V-IgG test in the fetus. The presence of B19V-IgG in fetal blood was accompanied by lower B19V-DNA levels and less severe clinical findings.
CONCLUSIONS: The lack of B19V-IgG in fetuses with B19V-derived anemia or hydrops is most likely due to a limited materno-fetal transfer of IgG and a poor fetal antibody response. Fetal B19V infection is poorly controlled in the absence of specific antibodies.
Johannes Weiffenbach; Rainer Bald; Karl-Philipp Gloning; Sabine Minderer; Barbara C Gärtner; Andrea Weidner; Monika Hanke; Martin Enders
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Publication Detail:
Type:  Journal Article     Date:  2012-01-24
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  205     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-08     Completed Date:  2012-03-27     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  782-8     Citation Subset:  AIM; IM    
Laboratory Prof. G. Enders and Partners and Institute of Virology, Infectious Diseases and Epidemiology, Stuttgart, Germany.
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MeSH Terms
Anemia / etiology
Antibodies, Viral / blood*
DNA, Viral / blood*
Erythema Infectiosum / immunology*,  virology
Fetal Blood / immunology*,  virology
Gestational Age
Hydrops Fetalis / etiology,  ultrasonography
Immunoglobulin G / blood
Immunoglobulin M / blood
Parvovirus B19, Human / immunology*
Pregnancy Complications, Infectious / immunology*,  virology
Retrospective Studies
Statistics, Nonparametric
Ultrasonography, Prenatal
Viral Load
Young Adult
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

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