Document Detail

Serologic responses to Pneumocystis carinii antigens in health and disease.
MedLine Citation:
PMID:  2299209     Owner:  NLM     Status:  MEDLINE    
Serum antibodies to human Pneumocystis carinii antigens were measured in greater than 400 specimens from different population groups by the immunoblotting technique. Serologic responses varied during the first 2 years of life, but in children greater than or equal to 2 1/2 years and in adults antibodies to a 40-kDa band were found in greater than 85% of the specimens; antigens to bands of 66, 92, and 116 kDa were also detected frequently. The prevalence of serum antibodies in immunosuppressed patients varied at different institutions and was usually lower than that of healthy controls. Seven (41%) of 17 patients with single episodes of pneumocystosis and 13 (93%) of 14 patients with recurrent episodes followed sequentially developed active serum IgM and/or IgG antibody responses to the 40-kDa antigen. Serologic responses to P. carinii were also detected, though less frequently, by immunofluorescence. These data suggest that the 40-kDa antigen is a major marker of P. carinii infection and that immunoblotting is useful in measuring serum antibody responses to the organism in both normal and immunocompromised hosts.
S L Peglow; A G Smulian; M J Linke; C L Pogue; S Nurre; J Crisler; J Phair; J W Gold; D Armstrong; P D Walzer
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  161     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-09     Completed Date:  1990-03-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-306     Citation Subset:  AIM; IM; X    
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications
Antibodies, Fungal / biosynthesis*
Antigens, Fungal / immunology*
Child, Preschool
Immune Tolerance
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Iowa / epidemiology
Opportunistic Infections / complications,  immunology
Pneumocystis / immunology*
Pneumonia, Pneumocystis / complications,  epidemiology*,  immunology
Grant Support
Reg. No./Substance:
0/Antibodies, Fungal; 0/Antigens, Fungal; 0/Immunoglobulin G; 0/Immunoglobulin M

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