Document Detail

Serologic prevalence of antibody to human herpesvirus type 8 in patients with various monoclonal gammopathies.
MedLine Citation:
PMID:  10721787     Owner:  NLM     Status:  MEDLINE    
Both viral and serologic studies have consistently shown an association of human herpesvirus type 8 (HHV-8) with Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease. The presence of HHV-8 DNA in patients with myeloma has been reported by some investigators but not substantiated by others. In addition, variable results have been obtained with serologic studies for HHV-8 in patients with myeloma and certain other monoclonal gammopathies (MG). We tested 238 coded serum or plasma samples from 96 patients with various MG for antibodies to lytic and latent HHV-8 antigens by indirect immunofluorescence. Thirty-four of 96 (35%) patients were positive for the lytic antibody, but none were positive for the latent antibody. Patients with kappa or lambda light chain myeloma were often positive for the lytic antibody when compared to patients with IgG or IgA myeloma (8 of 11 [73%] vs. 12 of 38 [32%], P = 0.033). The patients with light chain myeloma also were more likely to be positive when compared to patients with Waldenström's macroglobulinemia (WM) (4 of 15 [27%], P = 0.045) or AL amyloidosis (4 of 13 [31%], P = 0.047). Four of 9 (44%) patients with monoclonal gammopathy of undetermined significance (MGUS) were positive. However, 4 other patients who progressed from MGUS to myeloma were negative. Subgroup analysis of MG may help clarify the role of HHV-8 in these disorders.
S A Stone; E T Lennette; J T Newman; A Burfoot; M J Stone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  37     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-18     Completed Date:  2000-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM; X    
Baylor-Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA.
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MeSH Terms
Antibodies, Viral / blood*
Fluorescent Antibody Technique, Indirect
Herpesvirus 8, Human / genetics,  immunology*
Paraproteinemias / blood,  virology*
Polymerase Chain Reaction
Reg. No./Substance:
0/Antibodies, Viral

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