Document Detail

Serologic screening for herpes simplex virus type 2 in persons with human immunodeficiency virus.
MedLine Citation:
PMID:  23154653     Owner:  NLM     Status:  MEDLINE    
Screening for subclinical herpes simplex virus type 2 (HSV-2) may be a useful adjunct in human immunodeficiency virus (HIV) care. However, HSV-2 serological tests have been suggested to perform less well in HIV-infected populations. In this study, HerpeSelect HSV-2 ELISA was compared with the Sure-Vue Rapid HSV-2 Test for HSV-2 screening of sera from 310 HIV-infected persons receiving care at an HIV-dedicated clinic in the Southeastern United States. In the study, assay agreement and whether the performance of both tests, rather than 1 test alone, would improve screening accuracy were determined. Overall percent test agreement was 96%. Negative percent agreement was best at a HerpeSelect index value <0.90 and positive percent agreement was best at a HerpeSelect index value ≥3.0 (97% and 100%, respectively). Using the manufacturer's established cutoffs for a HerpeSelect positive test result versus negative test result, discordant results between assays occurred in 4% of the cases, and the majority of these cases occurred when the HerpeSelect index value was between 0.9 and 2.9. These data suggest a good correlation between the HerpeSelect and the Sure-Vue HSV-2 Rapid Test in a U.S. HIV-infected population and suggest that confirmatory testing may not help in HSV-2 diagnosis except in cases where HerpeSelect index values are between 0.9 and 3.0.
Nicholas J Van Wagoner; Rhoda Morrow; Jeannette Lee; Paula Dixon; Edward W Hook
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  346     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2013-09-23     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  108-12     Citation Subset:  AIM; IM    
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MeSH Terms
False Negative Reactions
False Positive Reactions
HIV Infections / complications*
Herpes Genitalis / blood,  complications*,  diagnosis
Herpesvirus 2, Human / isolation & purification*
Middle Aged
Sensitivity and Specificity
Serologic Tests / standards*
Young Adult
Grant Support
K23 AI097267/AI/NIAID NIH HHS; T32-A152069-07//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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