Document Detail

Seroepidemiology and risk factors of hepatitis B virus in Aden, Yemen.
MedLine Citation:
PMID:  21338959     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: There is little published data concerning hepatitis B virus (HBV) infection in Aden and no data concerning risk factors for infection. This study aimed to determine the prevalence of HBV infection and risk factors for infection in Aden, Yemen.
METHODS: A prospective cross sectional survey of individuals attending primary health care facilities was stratified by age and population size. Five hundred and thirty five participants were interviewed and serum was screened for the presence of Immunoglobin G HBV core antibodies (antiHBc). AntiHBc positive participants were tested for antibodies to hepatitis B surface antigen (HBsAg). A case-control analysis of risk factors for HBV was undertaken comparing risk factors between antiHBc positive cases and seronegative controls.
RESULTS: The age-standardized seroprevalence for antiHBc was 16.2% (95% confidence interval (CI) 13.1-19.3) and for HBsAg was 1.5% (95% CI 0.5-2.5). The seroprevalence of antiHBc and HBsAg was estimated to range from 5.5% and 0% in infants to 40% and 4.6% in adults, respectively (p<0.001). Age (AOR=1.03, 95% CI=1.01-1.05), household size (>5-9 members, AOR=2.9, 95% CI=1.1-7.6) and ownership of a landline telephone (AOR=2.8, 95% CI=1.3-5.8) were independent risk factors for HBV infection.
CONCLUSIONS: HBV is still a public health problem in this community, with older individuals having much higher prevalence than younger generations. The results of this study would categorise Aden as a low HBV endemic zone. Perinatal transmission does not seem to be a major route of transmission.
Amen Ahmed Bawazir; Christopher M Parry; C Anthony Hart; Tallal A Sallam; Nick Beeching; Luis E Cuevas
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Publication Detail:
Type:  Journal Article     Date:  2011-02-01
Journal Detail:
Title:  Journal of infection and public health     Volume:  4     ISSN:  1876-035X     ISO Abbreviation:  J Infect Public Health     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101487384     Medline TA:  J Infect Public Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  48-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.
Medical Faculty, Aden University, P.O. Box 6336, Khormaksar, Aden, Yemen; Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom.
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