Document Detail

Seroepidemiology of hepatitis A infection in India: changing pattern.
MedLine Citation:
PMID:  11497169     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recent changes in the epidemiology of hepatitis A virus (HAV) infection and the availability of effective vaccines have renewed interest in this infection. We determined the age-related prevalence of anti-HAV antibodies in India and looked for differences by known risk factors for HAV infection. METHODS: In this prospective study, serum samples obtained from 1612 subjects aged 1 to 60 at six centers in five cities (Calcutta, Cochin, Indore, Jaipur and Patna) during the period February to August 1998 were tested for anti-HAV antibodies. Demographic and socio-economic information was obtained by questionnaire. RESULTS: The overall seroprevalence rate was 65.9%, varying from 26.2% to 85.3% in various cities; there was no difference between males and females. Seropositivity increased with age from 52.2% in the 1-5 year age group to 80.8% in those aged 16 years or more. Seroprevalence rates were significantly lower in those aged 1-5 years compared with other age groups (p<0.0001). There was no difference in seroprevalence between those with monthly family income <Rs 5000 and >Rs 5001. Multivariate analysis showed that anti-HAV seroprevalence varied significantly by source of water supply, being highest when the supply was municipal. CONCLUSION: Our results indicate an epidemiological pattern of intermediate endemicity. This finding has public health implications as it indicates that a significant proportion of the Indian adolescent and adult population is at risk of HAV infection.
M L Mall; R R Rai; M Philip; G Naik; P Parekh; S C Bhawnani; B Olowokure; M Shamanna; J Weil
Related Documents :
17668279 - Comparison of the dynamics and correlates of transmission of herpes simplex virus-1 (hs...
19864749 - Comparison of h. pylori-gastritis among young and old patients by using "the modified s...
2557369 - Enterovirus-specific igm in the diagnosis of meningitis.
19912609 - Epidemiological survey on equine cryptosporidium and giardia infections in italy and mo...
8824989 - The lack of association between aging and postvaccination levels of igg antibody to cap...
23166759 - Sexual dimorphism in sturnira lilium (chiroptera, phyllostomidae): can pregnancy and pu...
12704779 - Increased brain white matter diffusivity in normal adult aging: relationship to anisotr...
22504289 - Fto, abdominal adiposity, fasting hyperglycemia associated with elevated hba1c in japan...
24463809 - Five years of kawasaki disease in the netherlands: a national surveillance study.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  20     ISSN:  0254-8860     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-08-10     Completed Date:  2001-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  132-5     Citation Subset:  IM    
Marwari Relief Society Hospital and The Calcutta Research Institute.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Child, Preschool
Confidence Intervals
Hepatitis A / epidemiology*,  immunology*
Hepatitis A Antibodies
Hepatitis Antibodies / blood
India / epidemiology
Reference Values
Seroepidemiologic Studies*
Sex Factors
Socioeconomic Factors
Water Supply
Reg. No./Substance:
0/Hepatitis A Antibodies; 0/Hepatitis Antibodies
Comment In:
Indian J Gastroenterol. 2002 Jan-Feb;21(1):40-1   [PMID:  11871843 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Iteroparous reproduction strategies and population dynamics.
Next Document:  Surgical anatomy of retrohepatic inferior vena cava and hepatic veins: a quantitative assessment.