Document Detail

Seroepidemiology of group I human coronaviruses in children.
MedLine Citation:
PMID:  17889596     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recently, several new human coronaviruses have been identified.
OBJECTIVES: To define the seroepidemiology of group I human coronaviruses.
STUDY DESIGN: A recombinant protein enzyme linked immunosorbent assay (ELISA) based on portions of the nucleocapsid protein of group I human coronaviruses was developed and was used to screen serum from 243 children and young adults.
RESULTS: For HCoV-229E, the percentages of seropositive individuals were 57.1% for infants <2 months old; 38.9% for infants 2-3 months old; 4.7% for infants 4-5 months old; 42.9-50.0% for infants 6-12 months old; 34.8-62.5% for individuals 1-20 years old. For HCoV-NL63, the percentages of seropositive individuals were 45.2% for infants <2 months old; 11.1% for infants 2-3 months old; 4.7% for infants 4-5 months old; 28.6-40.0% for infants 6-12 months old; 25.0-70.3% for individuals 1-20 years old.
CONCLUSIONS: Infection with these viruses is common in childhood though the prevalence of these viruses may vary from year to year.
Xiuping Shao; Xiaojie Guo; Frank Esper; Carla Weibel; Jeffrey S Kahn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-09-21
Journal Detail:
Title:  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology     Volume:  40     ISSN:  1386-6532     ISO Abbreviation:  J. Clin. Virol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-16     Completed Date:  2007-12-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9815671     Medline TA:  J Clin Virol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
Department of Pediatrics, Division of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA.
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MeSH Terms
Amino Acid Sequence
Antibodies, Viral / blood*
Child, Preschool
Coronavirus / classification,  immunology*
Coronavirus 229E, Human / immunology*
Coronavirus Infections / diagnosis,  epidemiology*
Enzyme-Linked Immunosorbent Assay
Infant, Newborn
Molecular Sequence Data
Nucleocapsid Proteins / chemistry,  genetics,  immunology*
Recombinant Proteins / genetics,  immunology
Seroepidemiologic Studies
Grant Support
R21 AI067762-01/AI/NIAID NIH HHS; R21AI067762-01/AI/NIAID NIH HHS; T32 AI07210-20/AI/NIAID NIH HHS
Reg. No./Substance:
0/Antibodies, Viral; 0/Nucleocapsid Proteins; 0/Recombinant Proteins; 0/nucleocapsid protein, Coronavirus

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