Document Detail

Seroepidemiological survey of hepatitis E in Hong Kong by recombinant-based enzyme immunoassays.
MedLine Citation:
PMID:  1359270     Owner:  NLM     Status:  MEDLINE    
The agent that causes the enterally transmitted form of non-A, non-B hepatitis has been cloned and called hepatitis E virus (HEV). We have carried out a seroepidemiological survey on the prevalence of hepatitis E in Hong Kong. In a retrospective study, serum from 394 patients with acute viral hepatitis and 355 healthy subjects was tested for antibodies to HEV (anti-HEV) with a recombinant-based enzyme immunoassay. 65 (16.5%) patients with hepatitis were positive for IgM anti-HEV and 23 (5.8%) were also positive for IgM anti-HEV. Of 18 patients diagnosed as having acute non-A, non-B, non-C hepatitis, 6 were IgM anti-HEV positive. 17 (6%) patients in whom acute hepatitis A was diagnosed were also infected with HEV. None of 70 patients with acute hepatitis B or C or exacerbation of chronic hepatitis B was IgM anti-HEV positive. 57 (16.1%) of the healthy subjects were positive for IgG anti-HEV. The prevalence of IgG anti-HEV was higher in subjects over 20 years old than in younger subjects (24% vs 4%, p < 0.0001). IgG anti-HEV was detected in 26% of subjects who were positive for IgG antibody to HAV and in 7% of those negative for that antibody (p < 0.0001). We demonstrated the validity of the recombinant-based enzyme immunoassays for the diagnosis of hepatitis E. Our results suggest that hepatitis E accounts for a third of non-A, non-B, non-C hepatitis in Hong Kong and that coinfection of hepatitis A and E can occur.
A S Lok; W K Kwan; R Moeckli; P O Yarbough; R T Chan; G R Reyes; C L Lai; H T Chung; T S Lai
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  340     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-17     Completed Date:  1992-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1205-8     Citation Subset:  AIM; IM    
Department of Medicine, Queen Mary Hospital, University of Hong Kong.
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MeSH Terms
Acute Disease
Hepatitis Antibodies / blood*
Hepatitis E / diagnosis,  epidemiology*,  immunology
Hong Kong / epidemiology
Immunoenzyme Techniques
Longitudinal Studies
Middle Aged
Recombinant Proteins
Retrospective Studies
Seroepidemiologic Studies
Serologic Tests / methods
Reg. No./Substance:
0/Hepatitis Antibodies; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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