Document Detail


Serodiagnosis of Mycobacterium avium complex pulmonary disease in the United States.
MedLine Citation:
PMID:  23100506     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Diagnosis of Mycobacterium avium complex pulmonary disease (MAC-PD) can be difficult. A previous study from Japan reported the usefulness of a serodiagnostic test for MAC-PD. The objective of this study was to evaluate the usefulness of the test in similar patients in the United States.One hundred patients with known or suspected MAC-PD and 52 healthy volunteers were enrolled into the study at National Jewish Health, Denver, Colorado. Serum glycopeptidolipid core IgA antibody levels were measured with an enzyme immunoassay (EIA) kit, and routine clinical evaluations were performed.The patients were divided into 2 groups based on clinical evaluation: 87 patients with MAC-PD that met American Thoracic Society criteria, and 13 who did not meet the criteria. The sensitivity and specificity (cut off point=0.3 U·mL(-1)) of the serodiagnostic test for diagnosing MAC-PD were 70.1% and 93.9%, respectively. Among the 44 patients in the MAC-PD group with 2 or more positive sputum cultures within the previous 6 months, sensitivity was 81.8%.The EIA kit demonstrated good sensitivity and specificity for the identification of MAC-PD, particularly in patients with 2 or more positive cultures, and may be useful for rapid MAC-PD diagnosis.
Authors:
Seigo Kitada; Adrah Levin; Melissa Hiserote; Ron J Harbeck; Chris A Czaja; Gwen Huitt; Shannon H Kasperbauer; Charles L Daley
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-25
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
National Hospital Organization National Toneyama Hospital.
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