Document Detail


Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.
MedLine Citation:
PMID:  22746839     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early pregnancy in 12% of islet autoantibody-positive mothers compared to 11% of the controls. In early pregnancy, mothers with HLA-DQ 2/2 or 2/X genotypes showed an increased risk for islet autoantibodies at delivery (OR 1.85; p=0.001). After adjusting for parity, maternal age, year of birth, and season of early pregnancy, early pregnancy EV-IgM combined with DQ2/2 or 2/X increased the risk for islet autoantibodies (OR 3.10; 95% CI 1; p=0.008). EV-IgM in early pregnancy increased the risk for islet autoantibodies at delivery in non-diabetic mothers with HLA-DQ 2/2 or 2/X type 1 diabetes risk genotypes.
Authors:
Sabina Rešić Lindehammer; Hanna Honkanen; William Allan Nix; Maarit Oikarinen; Kristian Francis Lynch; Ida Jönsson; Karel Marsal; Steven Oberste; Heikki Hyöty; Ake Lernmark
Related Documents :
9469279 - Three-dimensional ultrasonographic assessments of fetal development.
2245859 - Ultrasound-guided transcervical metroplasty.
1789919 - Report of the council on scientific affairs of the american medical association: ultras...
20387359 - Antenatal diagnosis of achondrogenesis type ii.
8272309 - An updated protocol for abortion surveillance with ultrasound and immediate pathology.
7876779 - A comparison of manual and ultrasound measurements of fundal height.
19783709 - Control of the estrous cycle to improve fertility for fixed-time artificial inseminatio...
18633979 - Performance of a styrene-degrading biofilter containing the yeast exophiala jeanselmei.
412999 - The reproductive cycle of the capuchin (cebus apella).
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-2
Journal Detail:
Title:  Viral immunology     Volume:  -     ISSN:  1557-8976     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801552     Medline TA:  Viral Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS , Malmö, Sweden .
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Performance of a New Blood Glucose Monitoring System in the Hands of Intended Users.
Next Document:  Non-Covalent Bicomponents Self-Assemblies on a Silicon Surface.