Document Detail


Serious community-acquired neonatal infections in rural Southeast Asia (Bohol Island, Philippines).
MedLine Citation:
PMID:  17262044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the bacterial etiology, clinical presentation and risk factors for outcome of serious community-acquired infections in young infants. STUDY DESIGN: Infants younger than 60 days, admitted for severe pneumonia or suspected sepsis/meningitis were prospectively evaluated using complete blood count, blood culture, chest radiograph, cerebrospinal fluid (CSF) culture in suspected meningitis. chi2 or Fisher's exact test and stepwise logistic regression were used for analysis. RESULTS: Thirty-four of 767 enrolled infants had a positive blood or CSF culture. Gram-negative bacteria were more frequent than Gram positive: overall (P=0.004), in those below 7 days of age (P=0.002) and among home deliveries (P=0.012). Case fatality rates were higher among infants below 1 week old (OR 4.14, P<0.001), those with dense (OR 2.92, P<0.001) or diffuse radiographic infiltrates (OR 2.79, P=0.003). CONCLUSIONS: Gram-negative enteric bacteria are the predominant causes of community-acquired infections in Filipino infants below 2 months old. Age below 7 days and radiographic pneumonia predicted death.
Authors:
B P Quiambao; E A F Simoes; E A Ladesma; L S Gozum; S P Lupisan; L T Sombrero; V Romano; P J Ruutu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-18
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  27     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
Affiliation:
Research Institute for Tropical Medicine, Manila, Philippines.
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Community-Acquired Infections / epidemiology*
Female
Gram-Negative Bacterial Infections / epidemiology*
Humans
Infant, Newborn
Logistic Models
Male
Philippines / epidemiology
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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