| Serious fatal and nonfatal non-AIDS-defining illnesses in Europe. | |
| | |
MedLine Citation:
|
PMID: 20700060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Little is known about the incidence and risk factors for serious non-AIDS-defining events. METHODS: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. RESULTS: Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05). CONCLUSIONS: Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need. |
| | |
Authors:
|
Amanda Mocroft; Peter Reiss; Jacek Gasiorowski; Bruno Ledergerber; Justyna Kowalska; Antonio Chiesi; Jose Gatell; Aza Rakhmanova; Margaret Johnson; Ole Kirk; Jens Lundgren; |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of acquired immune deficiency syndromes (1999) Volume: 55 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-22 Completed Date: 2010-10-08 Revised Date: 2011-09-06 |
Medline Journal Info:
|
Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
|
Languages: eng Pagination: 262-70 Citation Subset: IM; X |
Affiliation:
|
Research Department of Infection and Population Health, University College Medical School, London, UK. a.mocroft@ucl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acquired Immunodeficiency Syndrome
/
complications*,
mortality Age Factors Antiretroviral Therapy, Highly Active / mortality CD4 Lymphocyte Count Epidemiology / statistics & numerical data Europe / epidemiology Female Humans Incidence Kaplan-Meier Estimate Male Mortality Poisson Distribution Proportional Hazards Models Risk Factors |
| Investigator | |
Investigator/Affiliation:
|
M Losso / ; C Elias / ; N Vetter / ; R Zangerle / ; I Karpov / ; A Vassilenko / ; O Suetnov / ; N Clumeck / ; S De Wit / ; B Poll / ; R Colebunders / ; L Vandekerckhove / ; V Hadziosmanovic / ; K Kostov / ; J Begovac / ; L Machala / ; H Rozsypal / ; D Sedlacek / ; J Gerstoft / ; G Kronborg / ; T Benfield / ; M Larsen / ; J Gerstoft / ; T Katzenstein / ; A-B E Hansen / ; P Skinhøj / ; C Pedersen / ; K Zilmer / ; M Ristola / ; C Katlama / ; J-P Viard / ; P-M Girard / ; J M Livrozet / ; P Vanhems / ; C Pradier / ; F Dabis / ; D Neau / ; J Rockstroh / ; R Schmidt / ; J van Lunzen / ; O Degen / ; H J Stellbrink / ; S Staszewski / ; J Bogner / ; G Fätkenheuer / ; J Kosmidis / ; P Gargalianos / ; G Xylomenos / ; J Perdios / ; G Panos / ; A Filandras / ; E Karabatsaki / ; H Sambatakou / ; D Banhegyi / ; F Mulcahy / ; I Yust / ; D Turner / ; M Burke / ; S Pollack / ; G Hassoun / ; S Maayan / ; A Chiesi / ; R Esposito / ; I Mazeu / ; C Mussini / ; C Arici / ; R Pristera / ; F Mazzotta / ; A Gabbuti / ; V Vullo / ; M Lichtner / ; A Chirianni / ; E Montesarchio / ; M Gargiulo / ; G Antonucci / ; F Iacomi / ; P Narciso / ; C Vlassi / ; M Zaccarelli / ; A Lazzarin / ; R Finazzi / ; M Galli / ; A Ridolfo / ; A d'Arminio Monforte / ; B Rozentale / ; S Chaplinskas / ; R Hemmer / ; T Staub / ; P Reiss / ; J Bruun / ; A Maeland / ; V Ormaasen / ; B Knysz / ; J Gasiorowski / ; A Horban / ; E Bakowska / ; D Prokopowicz / ; R Flisiak / ; A Boron-Kaczmarska / ; M Pynka / ; M Beniowski / ; E Mularska / ; H Trocha / ; E Jablonowska / ; E Malolepsza / ; K Wojcik / ; F Antunes / ; E Valadas / ; K Mansinho / ; F Maltez / ; D Duiculescu / ; A Rakhmanova / ; E Vinogradova / ; S Buzunova / ; D Jevtovic / ; M Mokrá / ; D Stanekova / ; J Tomazic / ; J González-Lahoz / ; V Soriano / ; L Martin-Carbonero / ; P Labarga / ; S Moreno / ; B Clotet / ; A Carlos / ; S Moreno / ; B Clotet / ; A Jou / ; R Paredes / ; C Tural / ; J Puig / ; I Bravo / ; J M Gatell / ; J M Miró / ; P Domingo / ; M Gutierrez / ; G Mateo / ; M A Sambeat / ; A Karlsson / ; P O Persson / ; L Flamholc / ; B Ledergerber / ; R Weber / ; P Francioli / ; M Cavassini / ; B Hirschel / ; E Boffi / ; H Furrer / ; M Battegay / ; L Elzi / ; E Kravchenko / ; N Chentsova / ; G Kutsyna / ; S Servitskiy / ; S Antoniak / ; M Krasnov / ; S Barton / ; A M Johnson / ; D Mercey / ; A Phillips / ; M A Johnson / ; A Mocroft / ; M Murphy / ; J Weber / ; G Scullard / ; M Fisher / ; C Leen / ; B Clotet / ; R Paredes / ; F Antunes / ; B Clotet / ; D Duiculescu / ; J Gatell / ; B Gazzard / ; A Horban / ; A Karlsson / ; C Katlama / ; B Ledergerber / ; A D'Arminio Montforte / ; A Phillips / ; A Rakhmanova / ; P Reiss / ; J Rockstroh / ; J Lundgren / ; O Kirk / ; A Mocroft / ; N Friis-Møller / ; A Cozzi-Lepri / ; W Bannister / ; M Ellefson / ; A Borch / ; D Podlekareva / ; J Kjaer / ; L Peters / ; J Reekie / ; J Kowalska / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection.
Next Document: Detection of annexin a autoantibodies in sera from colorectal cancer patients.