Document Detail

A serious complication of selected internal radiation therapy: case report and literature review.
MedLine Citation:
PMID:  20693154     Owner:  NLM     Status:  MEDLINE    
The use of selective internal radiation therapy (SIRT) with SIR-Spheres(R) (Sirtex, Sydney, Australia) is increasingly recognized as a potential therapeutic modality of primary and secondary malignant liver tumors. A number of treatment-related complications have been described despite technical expertise and detailed pretreatment investigations to assess suitability. We describe a case of gastric ulceration from nontargeted deposition of SIR-spheres(R) in the gastric mucosa with life-threatening consequences. This case highlights the need for careful screening and appropriate patient selection, and the need to recognize ulceration from SIRT as a potential complication of treatment. The characteristic endoscopic, radiologic, and histopathologic findings are illustrated and recommendations are reviewed with regard to the current literature.
Katrin M Sjoquist; David Goldstein; Lourens Bester
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-08-05
Journal Detail:
Title:  The oncologist     Volume:  15     ISSN:  1549-490X     ISO Abbreviation:  Oncologist     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-27     Revised Date:  2012-09-19    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  830-5     Citation Subset:  IM    
Department of Medical Oncology, Prince of Wales Hospital, High Street, Randwick, NSW Australia.
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MeSH Terms
Adenocarcinoma / pathology,  radiotherapy*
Colorectal Neoplasms / pathology,  radiotherapy*
Gastric Mucosa / pathology
Middle Aged
Radiation Injuries / etiology*,  pathology
Stomach Ulcer / etiology*,  pathology
Yttrium Radioisotopes / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Yttrium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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