Document Detail


Serine racemase: an unconventional enzyme for an unconventional transmitter.
MedLine Citation:
PMID:  22847782     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The discovery of large amounts of D: -serine in the brain challenged the dogma that only L: -amino acids are relevant for eukaryotes. The levels of D: -serine in the brain are higher than many L: -amino acids and account for as much as one-third of L: -serine levels. Several studies in the last decades have demonstrated a role of D: -serine as an endogenous agonist of N-methyl-D: -aspartate receptors (NMDARs). D: -Serine is required for NMDAR activity during normal neurotransmission as well as NMDAR overactivation that takes place in neurodegenerative conditions. Still, there are many unanswered questions about D: -serine neurobiology, including regulation of its synthesis, release and metabolism. Here, we review the mechanisms of D: -serine synthesis by serine racemase and discuss the lessons we can learn from serine racemase knockout mice, focusing on the roles attributed to D: -serine and its cellular origin.
Authors:
Herman Wolosker; Hisashi Mori
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-31
Journal Detail:
Title:  Amino acids     Volume:  -     ISSN:  1438-2199     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Biochemistry, B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096, Haifa, Israel, hwolosker@tx.technion.ac.il.
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