| Serine racemase: an unconventional enzyme for an unconventional transmitter. | |
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MedLine Citation:
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PMID: 22847782 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The discovery of large amounts of D: -serine in the brain challenged the dogma that only L: -amino acids are relevant for eukaryotes. The levels of D: -serine in the brain are higher than many L: -amino acids and account for as much as one-third of L: -serine levels. Several studies in the last decades have demonstrated a role of D: -serine as an endogenous agonist of N-methyl-D: -aspartate receptors (NMDARs). D: -Serine is required for NMDAR activity during normal neurotransmission as well as NMDAR overactivation that takes place in neurodegenerative conditions. Still, there are many unanswered questions about D: -serine neurobiology, including regulation of its synthesis, release and metabolism. Here, we review the mechanisms of D: -serine synthesis by serine racemase and discuss the lessons we can learn from serine racemase knockout mice, focusing on the roles attributed to D: -serine and its cellular origin. |
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Authors:
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Herman Wolosker; Hisashi Mori |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-31 |
Journal Detail:
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Title: Amino acids Volume: - ISSN: 1438-2199 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biochemistry, B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096, Haifa, Israel, hwolosker@tx.technion.ac.il. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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