| Serine proteases of the human immune system in health and disease. | |
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MedLine Citation:
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PMID: 20537709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serine proteases form a large family of protein-cleaving enzymes that play an essential role in processes like blood coagulation, apoptosis and inflammation. Immune cells express a wide variety of serine proteases such as granzymes in cytotoxic lymphocytes, neutrophil elastase, cathepsin G and proteinase 3 in neutrophils and chymase and tryptase in mast cells. Regulation of proteolysis induced by these serine proteases is essential to prevent self-induced damage. Hence, there are specialized serine protease inhibitors, serpins, which are broadly distributed. Here, we discuss the function of human serine proteases in inflammation, apoptosis and tissue remodeling. Furthermore, we address their impact on development and progression of immune mediated-diseases. Understanding the mode of action of serine proteases will help to unravel molecular processes involved in immunological disorders and will facilitate the identification of new therapeutic targets. |
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Authors:
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Kirstin M Heutinck; Ineke J M ten Berge; C Erik Hack; Jörg Hamann; Ajda T Rowshani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-05-26 |
Journal Detail:
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Title: Molecular immunology Volume: 47 ISSN: 1872-9142 ISO Abbreviation: Mol. Immunol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-07-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905289 Medline TA: Mol Immunol Country: England |
Other Details:
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Languages: eng Pagination: 1943-55 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands. K.M.Heutinck@amc.uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Blood Coagulation Granzymes / physiology Humans Immune System / enzymology* Inflammation / etiology Mast Cells / enzymology Neutrophils / enzymology Serine Proteases / physiology* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Serine Proteases; EC 3.4.21.-/Granzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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