Document Detail

Serine protease and ovarian paracrine factors in regulation of ovulation.
MedLine Citation:
PMID:  23276950     Owner:  NLM     Status:  MEDLINE    
The controlled target extracellular matrix (ECM) degradation generated by serine protease and regulated by serine protease inhibitor and ovarian paracrine/autocrine factors is an event that affects a wide variety of physiological and pathological processes in the ovary. Evidence cumulated in the past decade clearly showed that the hormone-induced coordinated expression of the tissue-type PA (tPA) produced mainly by granulosa cells and oocyte, and its inhibitor PAI-1 secreted by theca cells in the preovulatory follicles may be responsible for a controlled and directed proteolysis leading to the rupture of selected follicles in the rat, monkey and other mammals. In recent years increasing evidence further demonstrated that oocyte maturation and ovulation may also be modulated by other serine protease and inhibitor, as well as endogenously- produced ovarian paracrine/autocrine factors. Thus, it is important to identify the interrelationship between the serine protease system and the multiple factors, and to know how they regulate the ovarian physiological and pathological processes during oocyte maturation and ovulation.
Yi-Xun Liu; Xi-Ming Liu; Liang-Fang Nin; Lei Shi; Su-Ren Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  650-64     Citation Subset:  IM    
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
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MeSH Terms
Follicle Stimulating Hormone / pharmacology
Gonadotropin-Releasing Hormone / pharmacology
Granulosa Cells / metabolism
Macaca mulatta
Matrix Metalloproteinases / physiology
Oocytes / physiology*
Ovary / metabolism
Ovulation / drug effects,  physiology*
Paracrine Communication / physiology*
Plasminogen Activator Inhibitor 1 / biosynthesis
Plasminogen Activators / physiology
Progesterone / physiology
Receptor, Epidermal Growth Factor / biosynthesis
Receptors, Progesterone / physiology
Serine Endopeptidases / metabolism*
Serpin E2 / physiology
Signal Transduction / physiology
Tissue Plasminogen Activator / metabolism
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 0/Receptors, Progesterone; 0/Serpin E2; 33515-09-2/Gonadotropin-Releasing Hormone; 57-83-0/Progesterone; 9002-68-0/Follicle Stimulating Hormone; EC, Epidermal Growth Factor; EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.-/Serine Endopeptidases; EC Plasminogen Activator; EC 3.4.24.-/Matrix Metalloproteinases

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