Document Detail

Serine protease inhibitor cvSI-1 potential role in the eastern oyster host defense against the protozoan parasite Perkinsus marinus.
MedLine Citation:
PMID:  19720077     Owner:  NLM     Status:  MEDLINE    
The serine protease inhibitor cvSI-1, purified from plasma of eastern oysters, inhibited the proliferation of the protozoan parasite Perkinsus marinus in vitro. In situ hybridization located cvSI-1 gene expression in basophil cells of the digestive tubules and cvSI-1 expression measured by real-time quantitative reverse transcriptase polymerase chain reaction was several hundred folds greater in digestive glands than in other organs examined or circulating hemocytes. cvSI-1 gene expression was also significantly greater in winter than in summer. Finally, cvSI-1 gene expression and plasma protease inhibitory activity in oysters selected for increased resistance to P. marinus were significantly greater than in unselected oysters. These findings support the hypothesis that cvSI-1 plays a role in eastern oyster host defense against P. marinus possibly through inhibition of parasite proliferation.
Jerome F La Peyre; Qing-Gang Xue; Naoki Itoh; Yanli Li; Richard K Cooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-05
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  34     ISSN:  1879-0089     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-10-23     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-92     Citation Subset:  IM    
Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge, LA 70803, USA.
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MeSH Terms
Alveolata / physiology*
Basophils / immunology
Crassostrea / enzymology,  parasitology*
Gene Expression Regulation
Host-Parasite Interactions / immunology*
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Serine Proteinase Inhibitors / genetics,  metabolism*
Reg. No./Substance:
0/RNA, Messenger; 0/Serine Proteinase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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