| Serine protease inhibitor cvSI-1 potential role in the eastern oyster host defense against the protozoan parasite Perkinsus marinus. | |
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MedLine Citation:
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PMID: 19720077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The serine protease inhibitor cvSI-1, purified from plasma of eastern oysters, inhibited the proliferation of the protozoan parasite Perkinsus marinus in vitro. In situ hybridization located cvSI-1 gene expression in basophil cells of the digestive tubules and cvSI-1 expression measured by real-time quantitative reverse transcriptase polymerase chain reaction was several hundred folds greater in digestive glands than in other organs examined or circulating hemocytes. cvSI-1 gene expression was also significantly greater in winter than in summer. Finally, cvSI-1 gene expression and plasma protease inhibitory activity in oysters selected for increased resistance to P. marinus were significantly greater than in unselected oysters. These findings support the hypothesis that cvSI-1 plays a role in eastern oyster host defense against P. marinus possibly through inhibition of parasite proliferation. |
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Authors:
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Jerome F La Peyre; Qing-Gang Xue; Naoki Itoh; Yanli Li; Richard K Cooper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-05 |
Journal Detail:
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Title: Developmental and comparative immunology Volume: 34 ISSN: 1879-0089 ISO Abbreviation: Dev. Comp. Immunol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708205 Medline TA: Dev Comp Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 84-92 Citation Subset: IM |
Affiliation:
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Department of Veterinary Science, Louisiana State University Agricultural Center, Baton Rouge, LA 70803, USA. jlapeyre@agctr.lsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alveolata
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physiology* Animals Basophils / immunology Crassostrea / enzymology, parasitology* Gene Expression Regulation Host-Parasite Interactions / immunology* RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Serine Proteinase Inhibitors / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Serine Proteinase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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