Document Detail

Serine biosynthesis and regulation in Haemophilus influenzae.
MedLine Citation:
PMID:  5305003     Owner:  NLM     Status:  MEDLINE    
Nutritional mutants of Haemophilus influenzae requiring l-serine for growth were shown to be deficient in their capacity to synthesize serine-phosphate from 3-phosphoglycerate. On the basis of the correlation between this block and the requirement for an exogenous supply of the amino acid, it was concluded that the "phosphorylated" pathway is the only pathway used by H. influenzae for serine biosynthesis. Serine inhibits serine-phosphate production, thereby regulating its own synthesis in a manner analagous to the Enterobacteriaceae. A mutant strain that required either serine or tryptophan for growth was normal in serine-phosphate synthesis and regulation. It was concluded that this strain probably has a tryptophan synthetase with an increased Michaelis constant for serine.
L I Pizer; M Ponce-de-Leon; J Michalka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  97     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1969 Mar 
Date Detail:
Created Date:  1969-05-15     Completed Date:  1969-05-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1357-61     Citation Subset:  IM    
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MeSH Terms
Carbon Isotopes
Glycerophosphates / metabolism
Glycine / metabolism
Haemophilus influenzae / metabolism*
Serine / biosynthesis*,  metabolism,  pharmacology
Reg. No./Substance:
0/Carbon Isotopes; 0/Glycerophosphates; 56-40-6/Glycine; 56-45-1/Serine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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