| Serial uterine artery Doppler velocity parameters and human uterine receptivity in IVF/ICSI cycles. | |
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MedLine Citation:
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PMID: 18241087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the predictive value of serial uterine artery Doppler ultrasound for embryo implantation in in-vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI) cycles. METHODS: This was a prospective observational study at the VU University Medical Center, Amsterdam. Patients with an indication for IVF or IVF-ICSI according to departmental protocol underwent controlled ovarian hyperstimulation followed by IVF or IVF-ICSI and embryo transfer and had serial Doppler ultrasound performed during this treatment cycle. Patient and cycle characteristics, number of conceptions and ongoing pregnancies and pulsatility index (PI) of both uterine arteries on different cycle days were assessed and results were compared between patients who conceived and those who did not. RESULTS: Of the 102 patients enrolled into the study, 83 underwent embryo transfer. Of these, 41 became pregnant and 42 did not (Group 1). Of the 41 pregnancies, 30 were ongoing (Group 2) and 11 miscarried (Group 3). Between Groups 1, 2 and 3, linear regression revealed no significant difference between any of the variables examined except in the quality of transferred embryos. There was no significant difference in the mean PI of the left and right uterine arteries on any day of the cycle, or in the change in PI during the cycle. Receiver-operating characteristics curves derived to determine the performance of PI to predict pregnancy outcome supported our findings that the uterine artery PI is not a suitable marker for identifying patients with implantation failure. Multivariate analysis showed no relationship between pregnancy and PI between groups, but it did show a relationship between pregnancy and some patient and cycle characteristics. CONCLUSION: In an unselected group of patients undergoing IVF or IVF-ICSI and embryo transfer, serial Doppler ultrasound examination of the uterine artery does not discriminate between cycles resulting in ongoing pregnancy, miscarriage and no pregnancy. |
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Authors:
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D A Hoozemans; R Schats; N B Lambalk; R Homburg; P G A Hompes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 31 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-03 Completed Date: 2008-08-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 432-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
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VU University Medical Center Amsterdam, IVF Center, Amsterdam, The Netherlands. da.hoozemans@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteries / ultrasonography Chorionic Gonadotropin / therapeutic use Embryo Implantation* Embryo Transfer Female Fertilization in Vitro* Humans Infertility, Female / therapy Pregnancy Pregnancy Outcome Prospective Studies Pulsatile Flow ROC Curve Sensitivity and Specificity Sperm Injections, Intracytoplasmic* Ultrasonography, Doppler / methods* Uterus / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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