| Serial ultrastructural studies of scrapie in hamsters. | |
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MedLine Citation:
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PMID: 2607015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report sequential studies of the ultrastructural neuropathology of the subcortical grey matter of hamsters infected with the 263K strain of scrapie virus. Vacuolation in this model develops relatively late in the incubation period, while tubulovesicular structures appear early. Furthermore, neuroaxonal dystrophy, accumulations of branching tubules, and neuronal change consisting of intracytoplasmic "whorls" of proliferating membranes constitute prominent features of scrapie-related neurodegeneration. |
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Authors:
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P P Liberski; D M Asher; R Yanagihara; C J Gibbs; D C Gajdusek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of comparative pathology Volume: 101 ISSN: 0021-9975 ISO Abbreviation: J. Comp. Pathol. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1990-02-12 Completed Date: 1990-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0102444 Medline TA: J Comp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 429-42 Citation Subset: IM |
Affiliation:
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Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders, Stroke, Bethesda, Maryland, MD 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / ultrastructure Axons / ultrastructure Brain / ultrastructure* Cricetinae Dendrites / ultrastructure Female Male Mesocricetus Microscopy, Electron Neurons / ultrastructure* Scrapie / pathology* Synaptic Vesicles / ultrastructure Vacuoles / ultrastructure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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