Document Detail

Serial ultrastructural studies of scrapie in hamsters.
MedLine Citation:
PMID:  2607015     Owner:  NLM     Status:  MEDLINE    
We report sequential studies of the ultrastructural neuropathology of the subcortical grey matter of hamsters infected with the 263K strain of scrapie virus. Vacuolation in this model develops relatively late in the incubation period, while tubulovesicular structures appear early. Furthermore, neuroaxonal dystrophy, accumulations of branching tubules, and neuronal change consisting of intracytoplasmic "whorls" of proliferating membranes constitute prominent features of scrapie-related neurodegeneration.
P P Liberski; D M Asher; R Yanagihara; C J Gibbs; D C Gajdusek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  101     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-02-12     Completed Date:  1990-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-42     Citation Subset:  IM    
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders, Stroke, Bethesda, Maryland, MD 20892.
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MeSH Terms
Astrocytes / ultrastructure
Axons / ultrastructure
Brain / ultrastructure*
Dendrites / ultrastructure
Microscopy, Electron
Neurons / ultrastructure*
Scrapie / pathology*
Synaptic Vesicles / ultrastructure
Vacuoles / ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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