| Serial studies of T-lymphocyte subpopulations in HIV seropositive haemophiliacs. | |
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MedLine Citation:
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PMID: 2957143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serial determinations of the numbers of peripheral blood T-lymphocyte subpopulations (T-helper/inducer and T-suppressor/cytotoxic cells) were made using monoclonal antibodies in 12 patients with haemophilia who were HIV antibody positive. Eleven patients were clinically severe and one clinically moderate. Follow-up studies for 12-42 months in nine patients showed persisting abnormalities in five patients, abnormalities which developed in three patients who were initially normal, and a return to normal findings in one patient who was initially abnormal. The remaining three patients were followed up for 3-4 months; two showed persisting abnormalities and one a return to normal. Persistent generalized lymphadenopathy was found in one patient who showed raised levels of T-suppressor cells initially and low levels of T-helper cells in the follow-up, but low T-helper cells persisting for up to 12 months were not necessarily associated with disease. |
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Authors:
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W S Mahir; R E Millard; P T Flute; D H Bevan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and laboratory haematology Volume: 9 ISSN: 0141-9854 ISO Abbreviation: Clin Lab Haematol Publication Date: 1987 |
Date Detail:
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Created Date: 1987-10-22 Completed Date: 1987-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7907061 Medline TA: Clin Lab Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: IM; X |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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diagnostic use Antibodies, Viral / analysis* Follow-Up Studies HIV / immunology* HIV Antibodies Hemophilia A / immunology* Humans Lymphatic Diseases / diagnosis, immunology Male T-Lymphocytes / classification*, cytology, immunology T-Lymphocytes, Cytotoxic / immunology T-Lymphocytes, Helper-Inducer / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antibodies, Viral; 0/HIV Antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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