Document Detail

Serial studies of T-lymphocyte subpopulations in HIV seropositive haemophiliacs.
MedLine Citation:
PMID:  2957143     Owner:  NLM     Status:  MEDLINE    
Serial determinations of the numbers of peripheral blood T-lymphocyte subpopulations (T-helper/inducer and T-suppressor/cytotoxic cells) were made using monoclonal antibodies in 12 patients with haemophilia who were HIV antibody positive. Eleven patients were clinically severe and one clinically moderate. Follow-up studies for 12-42 months in nine patients showed persisting abnormalities in five patients, abnormalities which developed in three patients who were initially normal, and a return to normal findings in one patient who was initially abnormal. The remaining three patients were followed up for 3-4 months; two showed persisting abnormalities and one a return to normal. Persistent generalized lymphadenopathy was found in one patient who showed raised levels of T-suppressor cells initially and low levels of T-helper cells in the follow-up, but low T-helper cells persisting for up to 12 months were not necessarily associated with disease.
W S Mahir; R E Millard; P T Flute; D H Bevan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  9     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM; X    
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Antibodies, Viral / analysis*
Follow-Up Studies
HIV / immunology*
HIV Antibodies
Hemophilia A / immunology*
Lymphatic Diseases / diagnosis,  immunology
T-Lymphocytes / classification*,  cytology,  immunology
T-Lymphocytes, Cytotoxic / immunology
T-Lymphocytes, Helper-Inducer / immunology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Viral; 0/HIV Antibodies

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