Document Detail

Serial sectioning and multiple level examination of endomyocardial biopsies for the diagnosis of myocarditis.
MedLine Citation:
PMID:  1788261     Owner:  NLM     Status:  MEDLINE    
To determine if serial sectioning and multiple level evaluation increase the sensitivity of endomyocardial biopsy for the detection of myocarditis, we prospectively studied all diagnostic endomyocardial biopsies between 1986 and 1989. Biopsies were embedded in paraffin, serially sectioned, and every 4-microns section was mounted in ribbons on glass slides. Every fifth slide was stained with hematoxylin and eosin and examined for myocarditis by the Dallas criteria (myocyte necrosis and inflammatory cells). Of a total of 153 biopsies, 20 cases (13%) were diagnostic of myocarditis on at least one section. Four biopsies (25%) were positive at slide Level 1, and 15 (75%) by slide Level 5; in five cases (25%), diagnostic foci were present only at or after slide Level 10. Multiple levels should be performed in the histologic evaluation of endomyocardial biopsies to increase the sensitivity of endomyocardial biopsy in the evaluation of myocarditis.
A P Burke; A Farb; M Robinowitz; R Virmani
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  4     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-03-24     Completed Date:  1992-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  690-3     Citation Subset:  IM    
Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, D.C.
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MeSH Terms
Biopsy / methods*
Endocardium / pathology*
Histological Techniques
Myocarditis / pathology*
Myocardium / pathology*
Sensitivity and Specificity

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