Document Detail

Serial respiratory adaptations and an alternate hypothesis of respiratory control in human pregnancy.
MedLine Citation:
PMID:  16311079     Owner:  NLM     Status:  MEDLINE    
This study determined the time course of changes in resting and exercising respiratory responses during the first half of human pregnancy, and examined the potential roles of plasma osmolality and the strong ion difference ([SID]) as mediators of pregnancy-induced increases in ventilation. Healthy active women (n = 11) were studied serially from 7 to 22 weeks gestation. Responses were compared with preconception data from 14 subjects (six of whom were tested in early pregnancy), and with late-gestation resting data from 10 additional women. Resting and exercising measurements included ventilation, PaCO2, progesterone, osmolality and [SID]. Results were analyzed using mixed-model linear regression. By 7 weeks gestation, increased ventilation resulted in a very large decrease in PaCO2 at rest and during moderate-intensity exercise. Large correlations (r > 0.5) between resting progesterone and PaCO2 support the traditional theory that circulating progesterone stimulates ventilation during pregnancy. The similar time course of changes and large correlations between raw and delta values of PaCO2 and each of plasma osmolality and [SID] also suggest that both variables may influence respiratory control at rest and during exercise in the first half of pregnancy. Future experiments should continue to explore the hypothesis that osmolality and [SID] contribute to pregnancy-induced respiratory changes.
Tracey L Weissgerber; Larry A Wolfe; Will G Hopkins; Gregory A L Davies
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-28
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  153     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-53     Citation Subset:  IM    
School of Physical and Health Education, Queen's University, Kingston, Ont., Canada K7L 3N6.
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MeSH Terms
Acclimatization / physiology*
Acid-Base Equilibrium / physiology
Blood Gas Analysis / methods
Exercise Test
Gestational Age
Osmolar Concentration
Partial Pressure
Physical Exertion / physiology
Pregnancy / blood,  physiology*
Pulmonary Gas Exchange / physiology
Pulmonary Ventilation / physiology*
Respiratory Mechanics / physiology*
Rest / physiology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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