Document Detail

Serial plasma lactate measurements in haematological patients with neutropenic fever.
MedLine Citation:
PMID:  19883163     Owner:  NLM     Status:  MEDLINE    
Elevated plasma lactate and impaired lactate clearance have been associated with poor outcome in patients with severe sepsis. No data are available on the kinetics or prognostic value of plasma lactate in haematological patients with neutropenic fever. A total of 70 haematological patients with 94 episodes of neutropenic fever were included into this prospective study during the period 2006-2008. The median age of the patients was 56 (range 18-70) y. Nineteen patients received therapy for acute myeloid leukaemia and 51 patients received autologous stem cell transplantation. At the onset and on days 1, 2, and 3 of each neutropenic fever episode, plasma lactate and serum C-reactive protein were determined. Criteria for severe sepsis were fulfilled in 13 neutropenic episodes. An elevated plasma lactate level was infrequent at the start of neutropenic fever (5%). There was no association of lactate level with the development of severe sepsis. Two patients died of septic shock, 1 patient with an exceptionally high and increasing level of lactate and the other patient with a normal lactate level. An elevated plasma lactate level at the start of neutropenic fever is not common and does not indicate severe sepsis, but high lactate and an impaired lactate decrease may signify a fatal course in neutropenic fever.
Auni Juutilainen; Sari H?m?l?inen; Irma Matinlauri; Taru Kuittinen; Tapio Nousiainen; Kari Pulkki; Irma Koivula; Esa Jantunen
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  42     ISSN:  1651-1980     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  102-8     Citation Subset:  IM    
Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
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MeSH Terms
C-Reactive Protein / analysis
Hematologic Neoplasms / complications*
Lactic Acid / blood*
Middle Aged
Opportunistic Infections / diagnosis*,  pathology
Plasma / chemistry*
Predictive Value of Tests
Prospective Studies
Young Adult
Reg. No./Substance:
50-21-5/Lactic Acid; 9007-41-4/C-Reactive Protein

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