| Serial plasma concentrations of atrial natriuretic peptide, plasma renin activity, aldosterone, and antidiuretic hormone in neonates on extracorporeal membrane oxygenation. | |
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MedLine Citation:
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PMID: 11820219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To obtain information on water and salt regulating hormones and volume homeostasis during neonatal extracorporeal membrane oxygenation (ECMO), serial determinations of atrial natriuretic peptide (ANP), plasma renin activity (PRA), aldosterone (Aldo), antidiuretic hormone (ADH), colloid-osmotic pressure (COP), osmolality (Osmol), and central venous pressure (CVP) before, during, and after neonatal ECMO in 10 neonates with meconium aspiration syndrome (MAS) were carried out. Mean gestational ages and birth weights were 41(+3) weeks (39(+6) - 42(+4)) and 4,063 gm (3,500-4700), respectively; mean age at start and duration of ECMO 29.3 (14-69) and 152.6 hr (92-267), respectively. Plasma ANP (mean +/- SD) was 67.8+/-69.1 pmol/L before, decreased to 33.3+/-22.1 (not significant) pmol/L during, and significantly increased to 274.6+/-131.8 pmol/L after ECMO (p < 0.05). ANP correlated positively with CVP (r = 0.63; p < 0.001). Pre-ECMO PRA, Aldo, and ADH were comparable to those described earlier in normal neonates, decreased during (p < 0.001 for Aldo; p < 0.05 for PRA and ADH) and either remained elevated (PRA, p < 0.001; Aldo, p < 0.05) or decreased (ADH) after ECMO. COP and Osmol remained unchanged. Neonatal ECMO for MAS is characterized by circulatory and osmotic equilibrium. It is suggested that circulating volume contracts during and expands after neonatal ECMO for MAS. |
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Authors:
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Ben A Semmekrot; Gerard J Pesman; Paul N Span; C G J Sweep; Arno F J van Heijst; Leo A H Monnens; Margot van de Bor; Ronald B Tanke; Frans H J M van der Staak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 48 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 2002 Jan-Feb |
Date Detail:
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Created Date: 2002-01-29 Completed Date: 2002-07-11 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 26-33 Citation Subset: IM |
Affiliation:
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Department of Neonatology, University of Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood* Atrial Natriuretic Factor / blood* Blood Pressure Central Venous Pressure Electrolytes / blood, urine Extracorporeal Membrane Oxygenation* Heart Rate Humans Infant, Newborn Osmolar Concentration Osmotic Pressure Renin / blood* Serum Albumin Urine Vasopressins / blood* |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 0/Serum Albumin; 11000-17-2/Vasopressins; 52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
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