Document Detail

Serial phospholipid analysis in preterm infants: comparison of Exosurf and Survanta.
MedLine Citation:
PMID:  10213294     Owner:  NLM     Status:  MEDLINE    
The initial clinical response to synthetic or natural surfactant is different and long-term complications from meta-analysis suggest that bronchopulmonary dysplasia and retinopathy of prematurity may be increased in infants given synthetic surfactant. It is possible that this is due to differences in the phospholipid composition of lung fluid following administration of these surfactants. Infants less than 32 weeks gestation with respiratory distress syndrome (RDS) were randomly assigned to receive either Exosurf, an artificial surfactant, or Survanta, a natural surfactant. Endotracheal or hypopharyngeal aspirates were obtained from these infants and from control infants who had normal lungs. The aspirates were taken prior to and up to 28 days following surfactant administration. The different phospholipids were separated by thin layer chromatography and expressed as a percent of total phospholipid measured. Infants with normal lungs had a higher proportion of phosphatidylcholine than those with RDS prior to treatment. The infants with normal lungs had a greater proportion of phosphatidylinositol in their lung aspirates than both treatment groups at 24 h. Infants in the Survanta group had a higher proportion of phosphatidylglycerol at 48 h than the group with normal lungs. No other differences were found in phospholipid composition up to 28 days. There were no major differences in the phospholipid profile in infants with RDS treated with either Exosurf or Survanta. In conclusion, neither the clinical differences initially seen between infants treated with either Exosurf or Survanta, nor the long-term outcome could be explained by the phospholipid composition of serial samples of lung aspirates.
J Lloyd; D A Todd; E John
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Early human development     Volume:  54     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-07-13     Completed Date:  1999-07-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  157-68     Citation Subset:  IM    
Department of Neonatal Medicine, Westmead Hospital, NSW, Australia.
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MeSH Terms
Analysis of Variance
Biological Products*
Chi-Square Distribution
Chromatography, Thin Layer
Drug Combinations
Fatty Alcohols / therapeutic use*
Infant, Newborn
Infant, Premature
Phospholipids / analysis*
Polyethylene Glycols / therapeutic use*
Pulmonary Surfactants / therapeutic use*
Respiratory Distress Syndrome, Newborn / drug therapy*,  metabolism
Treatment Outcome
Reg. No./Substance:
0/Biological Products; 0/Drug Combinations; 0/Fatty Alcohols; 0/Phospholipids; 0/Polyethylene Glycols; 0/Pulmonary Surfactants; 107-73-3/Phosphorylcholine; 108778-82-1/beractant; 99732-49-7/Exosurf

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