| Serial optical coherence tomography-based observation of strut coverage on drug-eluting stent crossing side-branch vessels. | |
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MedLine Citation:
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PMID: 23117310 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Serial changes in strut coverage of drug-eluting stents (DESs), which are placed across side-branch vessels, remain unclear. METHODS: The changes in strut coverage of DESs crossing side-branch vessels (size ≥2.0 mm) were serially evaluated by optical coherence tomography (OCT) in 30 patients at 9 months and 2 years after the index DES implantation. DESs were paclitaxel-eluting stents (PESs), sirolimus-eluting stents (SESs), and zotarolimus-eluting stents (ZESs), each in 10 patients. Measured neointimal hyperplasia (NIH) thickness of 0 μm on OCT was defined as an uncovered strut. RESULTS: The percentage of uncovered side-branch struts significantly decreased from 55.7 ± 39.9% to 36.6 ± 32.0% (P<.0001) on serial follow-up: PES, 93.4 ± 10.5% to 67.6 ± 24.2%, P=.018; SES, 47.5 ± 34.4% to 29.6 ± 24.1%, P=.036; and ZES, 26.2 ± 34.8% to 12.4 ± 19.0%, P=.028. Among covered side-branch struts, the overall percentage of struts with NIH thickness more than 30 μm significantly increased from 36.3 ± 37.4% to 51.0 ± 36.0% (P<.0001). However, compared to other DES types, a significant increase in relatively thin NIH (0 to 30 μm) was observed in PESs (1.6 ± 3.4% to 17.4 ± 16.0%; P=.018). CONCLUSION: Serial follow-up OCT examination showed a significant decrease in the percentage of uncovered side-branch struts, and the coverage pattern differed with DES type. |
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Authors:
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Seung-Yul Lee; Jung-Sun Kim; Dong-Ho Shin; Byeong-Keuk Kim; Young-Guk Ko; Donghoon Choi; Yangsoo Jang; Myeong-Ki Hong |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of invasive cardiology Volume: 24 ISSN: 1557-2501 ISO Abbreviation: J Invasive Cardiol Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917477 Medline TA: J Invasive Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 569-73 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, 120-752 Seoul, South Korea. mkhong61@yuhs.ac. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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