Document Detail

Serial neurophysiological studies of intramuscular botulinum-A toxin in humans.
MedLine Citation:
PMID:  7969239     Owner:  NLM     Status:  MEDLINE    
To characterize the time course of intramuscular botulinum toxin-induced paresis, we serially performed electrophysiological measurements and recorded the sonographic size of an extensor digitorum brevis (EDB) muscle in 10 human subjects before and after injecting the EDB with 10 units of botulinum-A toxin. All EDB CMAPs decreased within 48 h, with peak decline at day 21 (8.3 +/- 3.1 mV to 3.0 +/- 0.9 mV). Decline of mean rectified voltage during maximal voluntary contraction of the EDB paralleled the change in CMAP amplitude. Average decrements to 2-Hz repetitive stimulation never exceeded 6% (day 42) and exercise failed to facilitate significantly CMAP amplitude. Atrophy peaked at day 42. The F-wave to M-wave ratio increased at day 2; silent periods did not change. Our findings confirm a primary peripheral action of the toxin, but a superimposed, transient central effect of the drug cannot be excluded. Intramuscular injections into EDB provide a useful model for studying chemodenervation effects.
J A Hamjian; F O Walker
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  17     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1994-12-22     Completed Date:  1994-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1385-92     Citation Subset:  IM    
Department of Neurology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1078.
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MeSH Terms
Botulinum Toxins / administration & dosage,  toxicity*
Electric Stimulation / methods
Electromyography / methods
Injections, Intramuscular
Middle Aged
Muscles / drug effects*,  physiology,  physiopathology
Neuromuscular Junction / drug effects,  physiology
Paralysis / chemically induced,  physiopathology*
Time Factors
Reg. No./Substance:
0/Botulinum Toxins

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