| Serial measurements of plasma renin activity, aldosterone and cortisol during percutaneous transluminal angioplasty of the renal artery in man. | |
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MedLine Citation:
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PMID: 2977883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifteen patients (eight men, seven women) with hypertension and renal artery stenosis underwent dilation of the stenosis by percutaneous transluminal renal angioplasty (PTRA). During and shortly after this treatment the effects on the renin-angiotensin-aldosterone system and blood pressure were studied. Plasma renin activity (PRA) was measured in peripheral blood and in renal venous blood during the PTRA. PRA increased in peripheral blood during PTRA as a result of an immediate significant rise in renal venous plasma renin activity by 132 +/- 134% (P less than 0.01) on the dilated side. PRA in the contralateral renal vein was close to that in peripheral blood. Within 10 min after PTRA there was a significant increase in serum aldosterone from 439 +/- 343 to 774 +/- 635 pmol 1-1 (P less than 0.025), while serum cortisol remained unchanged. The aldosterone increase was most probably mediated by angiotensin II. Systolic and diastolic blood pressures were unchanged during PTRA in spite of renin and aldosterone increases, suggesting that antihypertensive factors counteract the pressor effects of a physiologically relevant increase in PRA. |
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Authors:
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A Hägg; L E Lörelius; C Mörlin; L Wide |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 134 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-06-27 Completed Date: 1989-06-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 473-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University Hospital, University of Uppsala, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aldosterone / blood* Angioplasty, Balloon* Female Hemodynamics Humans Hydrocortisone / blood* Hypertension, Renal / blood, physiopathology, therapy* Male Middle Aged Renal Artery Obstruction / blood, physiopathology, therapy* Renin / blood* Renin-Angiotensin System |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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