Document Detail

Serial measurements of exercise performance in pediatric heart transplant patients using stress echocardiography.
MedLine Citation:
PMID:  21492351     Owner:  NLM     Status:  In-Data-Review    
Yeung JP, Human DG, Sandor GGS, De Souza AM, Potts JE. Serial measurements of exercise performance in pediatric heart transplant patients using stress echocardiography. Pediatr Transplantation 2011: 15: 265-271. © 2011 John Wiley & Sons A/S. Abstract:  Heart transplantation is an increasingly acceptable therapeutic option for children with end-stage and complex congenital heart disease. With advances in surgery, immunosuppression, and follow-up care, functional outcomes need to be evaluated. We report the results of serial exercise testing performed using stress echocardiography in a cohort of pediatric HTP. HTP (n = 7) exercised on a semi-recumbent ergometer to volitional fatigue. Echocardiography-Doppler measurements, HR, and blood pressure were taken at rest and during staged exercise. Results were compared with healthy CON (n = 12). HTP did significantly less work during exercise (940 vs. 1218 J/kg, p < 0.03). Their SVI (33 vs. 49 mL/m(2) , p < 0.003), CI (5.16 vs. 9.25 L/min/m(2) , p < 0.0005), and HR (162 vs. 185 bpm, p < 0.02) were lower at peak exercise. HTP had a lower SF at peak exercise (48% vs. 52%, p < 0.03) and an abnormal relationship between the MVCFc and σPS. During follow-up, hemodynamics and left ventricular function remained relatively constant in HTP. HTP are able to exercise safely; however, their exercise tolerance is reduced, and hemodynamics and contractility are diminished. Over time, their hemodynamics and left ventricular function have remained relatively constant.
Joanne P Yeung; Derek G Human; George G S Sandor; Astrid M De Souza; James E Potts
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric transplantation     Volume:  15     ISSN:  1399-3046     ISO Abbreviation:  Pediatr Transplant     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802574     Medline TA:  Pediatr Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Department of Pediatrics Division of Cardiology, Department of Pediatrics, BC Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
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